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The SSC is grateful for the generous participation of many members in the generation of good standards data, which underpins so much of the work of the SSC and ISTH. We have created this record for standards adopted by WHO/ECBS in recent years as a way of acknowledging the input of time, expertise and reagents. We may be missing information for some older standards. Please advise Cary Clark (headquarters@isth.org) of any additional information.

Plasma Standards • Concentrate Standards • Fibrinolytics and Anticoagulants

Plasma Standards

2nd International Standard for Antithrombin, plasma (93/768)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Sadaaki Iwanaga
Co-chairs:R.M. Bertina, Born Dahlbäck, Takehiko Koide, David Lane

Trevor Barrowcliffe, Jane Watton (Haematology); Alan Heath (Informatics Laboratory)K Benford, E Briet, A-M Fischer, D J Warnuek, S Fedy, J Conard, J Fareed, M Johnston, J Maynard, P Cooper, F E Preston, H P Beeser, H Ridgeway, J Lloyd, E Duncan, J Watton, T W Barrowcliffe, A Tripodi, J Brandt, C Wagner, A-S Carlstrom, U Abildgaard, J Arnout

1994

3rd International Standard for Antithrombin, plasma

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Herbert C Whinna
Co-chairs:Francesco Bernardi, Elaine Gray, Tilman Hackeng, Steven Kitchen, Richard Marlar, P Meijer, Laurent Mosnier

John Hogwood, Michelle Hamill, Peter Rigsby, Elaine Gray

D Adcock, L Desjardin, J Amiral, P Baker, N Barat, F Nicham, M Bono, C Caron, G Hickman, J Conkie, P Cooper,
E Biguzzi, D Asti, D Foulon, L Germain, C Ludlam, J Hogwood, H Hoogendoorn,
A Jones, T Kerim, B Kerbl, A Lichte, R Luddington, S Nair, A Srivastava, J Rentenaar, A Riddell, J Jespersen, J Sidelmann, K Trumbull, K Villadsen, A-M Hvas, Renata Zadro

2010

1st International Standard for C-1 Inhibitor, Plasma (08/262)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment

Chair:Thomas Renne
Co-chairs: David Gailani, Keith McCrae

Craig Thelwell, Peter Rigsby, Colin Longstaff

S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz

2010

3rd International Standard Factors II, VII, IX, X, plasma (99/826)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Donna DiMichele
Co-Chairs:Jørgen Ingerslev, Christine Lee, Koen. Mertens, Claude G Negrier, Johannes Oldenburg,Dorothea Scandella, Akira Yoshioka

Elaine Gray, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory)R Bader, J Gillissen, P Braun, C Lessard, M Seidler, K Denson, D Howarth, F Ofosu, F van der Meer, R Parkinson, S Lees, S Kitchen, B Sampson, J Lloyd, J Ingerslev, H Ridgeway, L Lottin, M Robers, H Lehmann, L Weller, R Iampetrio, S Thomas

2001

4th International Standard Factors II, VII, IX, X, plasma (09/172)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Alok Srivastava
Co-Chairs: Jan Astermark, Kathelijn Fischer, Charles Hay, Claude Negrier, Johannes Oldenburg, Flora Peyvandi, Edward Tuddenham, Leonard Valentino

Elaine Gray, Helen Barson, Jason Hockley, Peter RigsbyR Zadro, J.M.Rentenaar, K Sukhu, J Jespersen, J Sidelmann, S Nair, M Timme, R Luddington, M Boylan, R Bader, C Caron, K Villadsen, A-M Hvas, C Ludlam, L Germain, J Amiral, D Adcock, L Desjardin, A Riddell, M Bono, K Trumbull, W Olend, B Kerbl, D Foulon, H Hoogendoorn, J McGrath, H Barson, M Beeharry, N Barat, F Nicham, J Conkie, G Hickman, S Rosen, A Bowyer, L Saminaden, J Gillissen, K Bradley, C Loh, A Jones, T kerim, N Lucchesi, D Gambelli

2010

1st International Standard for Blood Coagulation Factor V in Plasma, Human (03/116)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and Factor IX

Chair:Koen Mertens
Co-Chairs:
Joan Cox Gill, Christine Lee, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg

Anthony R. Hubbard (Haematology); Suzanne Johnes (Informatics Laboratory)A Hunfeld, J M Rentenaar, R Bader, S Kitchen, A Bowyer, K Trumbull, M Shima, C Lee, A Riddell, C Caron, H Metzner, F Nicham, J Weinberger, B Kerbl, A Hubbard, L J Weller, S Berrier, R Veinotte, S Duff, S Rosen, C Loh, P Giangrande, K Sukhu, J V Lloyd, E Duncan, A Tosetto, A Cappelletti, JCJ Eikenboom, D Harz

2005

5th International Standard for Blood Coagulation Factor VIII and Von Willebrand Factor in Plasma, Human (02/150)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and Factor IX

Chair:Donna DiMichele
Co-Chairs:Christine Lee, Koen Mertens, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg

Von Willebrand Factor

Chair:Robert R Montgomery
Co-Chairs:Giancarlo Castaman, Jeroen C.J. Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, David Lillicrap, Claudine Mazurier

Anthony R Hubbard (Haematology), Alan B Heath (Informatics Laboratory)A Yoshioka, K Sukhu, P Giangrande, R Bader, J V Lloyd, J Endres, C Eby, R Kotitschke, S Joyon, H Metzner, C andreini, S Rosen, S Duff, S Cinotti, C Watson, M Griffiths, M G Riera, M Ledford, F Rodeghiero A Tosetto, J M Lusher, C Wiseman, M Wolf, P Turecek, E Favaloro, A Hunfeld, K Trumbull, C Mazurier, B Samor, M Knorst, S Bevan, L Weller, J Patzke, C A Ludlam, C Michalski, D A Triplett, S Kitchen, B Sampson, C A Lee, A Riddell, M Grimaux, J Ingerslev, C Caron, C M Eckmann

2003

1st International Standard for Blood Coagulation Factor XI in Plasma, Human (04/102) and Calibration of Blood Coagulation Factor XI in SSC Secondary Plasma Standard Lot#3

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Kallikrein-Kinin System

Chair:Keith R McCrai
Co-Chairs:
Raul A DeLa Cadena, David Gailani Michael J Gallimore, Hidehiko Saito, Alvin H Schmaier

Working Group on Plasma Coagulation Standards

Chair:Jane Lenahan

Elaine Gray, Stephen Thomas (Haematology); Peter Rigsby (Informatics Laboratory)R Bader, A Bianchi Bonomi, A Bellisario, A Starace, S Antimo, A Birchall, A Abrahams, P Bolton-Maggs, D Shanks, S Duff, M Boylan, E Duncan, C Casey, D Elminger, T Fanella, D Gailani, G Baxter, J Gillissen, K Bradley, P Harper, L Glogoski, A Hunfeld, S Rosenkranz, L Ivey, W Jones, S Harris, B Kerbl, S Kitchen, A Bowyer, D Lawson, P Braun, L Lim, M Taylor, I Mackie, A Lawrie, K Mertens, C Eckmann, G Rautmann, U Selgsohn, A Zivelin, I Tamarin, K Sukhu, S Thomas, K Trumbull, B Phillips, J Weinberger, D Krause, L Weller

Oct. 2005

1st International Standard for Factor XIII, Plasma (02/206)

Subcommittee

Working Party

NIBSC PersonnelParticipantsWHO Establishment
Factor XIII

Chairman: Robert Ariens
Co-Chairs:Paul Bishop, Akitada Ichinose

Factor XIII Standardization WP(Akitada Ichinose,Chair, Trevor Barrowcliffe, Laszlo Muszbek, Rainer Seitz, Robert. Ariens)Sanj Raut, Elizabeth Merton, Trevor Barrowcliffe (Haematology);Peter Rigsby, Daniella Belgrave (Informatics Laboratory)M. Arai, R. Ariens, M. Boothby, N. Booth, N. Moore, A. Birchall, G. Castaman, A Tosetto, C. Caron, M. Dreyfus, M. Hanss, A. Hunfeld, H.I. Hassouna, A. Inbal, A. Ichinose, S.M. Kang, H.P. Kohler, V. Schroeder, K. Christian, S. Kingsland, M.Knorst, D.S. Lee, J.C.M. Meijers, H. Metzner, L. Muszbek, B. Polack, S Raut, E. Merton, K. Sukhu, M. Wilmer, K. Rudin, M. Wilkens

2004

2nd International Standard for Fibrinogen, plasma (98/612)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinogen

Chair:Michael W Mosesson
Co-chairs:Frank Brosstad, Michio Matsuda, Willem Nieuwenhuizen, Ron McIntosh

Patrick J Gaffney, Colin M Whitton, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory)E Bovill, H Lang, J-D Schreiber, D Howarth, W Nieuwenhuizen, S Kitchen, I J Mackie, A S Lawrie, J Conkie, R Bader, J A Ruiz, M Boldt, J L Martinoli, C Whitton

1999

1st International Standard for Protein C, Plasma, Human (86/622)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Protein C and S

Chair:RM Bertina
Co-Chairs:RR Montgomery, JH Griffin, JP Miletich, AR Hubbard, I Pabinger, AW Broekmans

Anthony R Hubbard, Duncan P Thomas (Haematology)U Becker, RM Bertina, B Chambrette, A Dessauer, D Green, JH Griffin, AR Hubbard, H Lang, MJ Larrieu, PM Mannucci, RA Marlar, K Mertens, S Rosen, N Sala, I Scharrer, H Vinazzer, S Wasi

1987

2nd International Standard for Protein C, plasma (02/342)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Elaine Gray
Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna

Elaine Gray, William Pickering (Haemostasis); Peter Rigsby (Informatics Laboratory);J Amiral, E Biguzzi, D Asti, P Baker, P Braun, S Berrier, C Bisson, P Gärtner, M Johnston, J McGrath, B Kerbl, S Kitchen, P Cooper, C Loh, M Harvey, C Michalski, S Morriso, I Pabinger-Fasching, W Pickering, M Ramondetta, L Leo, J Rentenaar, C-H Toh, A Smith, K Trumbull, B Phillips, B Woodhams, R Zadro

2006

1st International Standard for Protein S, Plasma, Human (93/590)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment

Chair:Takehiko Koide
Co-Chairs:
RM Bertina, Bjorn Dahlback, Sadaaki Iwanaga, David Lane

Anthony R Hubbard (Haematology)AM Burn, F Franchi, A Tosetto, RM Bertina, J Amiral, I Walker, J Conkie, J J Michiels, HHDM van Vliet, I Pabinger, B Woodhams, M Burgess-Wilson, H Lang, B Dahlback, R A Marlar, D Meyer, F E Preston, P Cooper, A R Hubbard, A Lawrie

1995

2nd International Standard for Protein S, plasma (03/228)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Elaine Gray
Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna

Anthony R Hubbard, Lynne Weller (Haemostasis); Alan B Heath (Informatics Laboratory)E Biguzzi, D Asti, P Baker, M Stegnar, A Smith, M Johnston, B Kerbl, M Smith, A R Hubbard, L J Weller, J C J Eikenboom, R Marlar, I Pabinger, R Zadro, K Mertens, J Rentenaar, J Patzke, D D Castellone, S Berrier, M-O Couche, S Lees, P Cooper, S Kitchen, J Conkie, C Legnani, G Palareti

2006

1st IS for Tissue Plasminogen Activator (tPA) Antigen, Plasma (94/730)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Colin Longstaff
Co-Chairs:
Carl-Erik H. Dempfle, Ann Gils, D Hendriks, Osamu Matsuo, Michael E. Nesheim

Colin Whitton, Peter Rigsby, Colin LongstaffYves Gourmelin, Stéphanie Berrier, Barbara Kerbl, Jean Amiral, Ann Rumley/Gordon Lowe, Norma Moore/Nuala Booth, Tetsumei Urano, Pamela Dawson, Colin Whitton, Annika Sköld, Renate Beckmann, Paul Declerck, J.C.M. Meijers

2007

4th International Standard for Thromboplastin, Rabbit, Plain

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Control of Anticoagulation

Chair:Sam Schulman
Co-Chairs:
Mike Greaves, Job Harenberg, Clive Kearon, Michael Laposata, John Olson, Gualtiero Palareti, F.R. Rosendaal, AMHP van den Besselaar


P Angchaisuksiri, K Aryurachai, M Borrell, V Chantarangkul, A Tripodi, K Denson, T Gago, P Herbel, A Jünschke, W Plesch, M Johnston, S Kitchen, C Legnani, T Lindahl, R Manning, M Martinuzzo, D Mezzano, N Opartkiattikul, K Overgaard, J Jespersen, V Pengo, M Persson, A Hillarp, R Redaelli, F Baudo, P Rojnuckarin, B Akkawat, E Witteveen, AMHP van den Besselaar, H Wada

2005

6th IS Factor VIII/von Willebrand factor Plasma (WHO/BS/09.2116)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX<

Chair:Alok Srivastava
Co-Chairs:
Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham

von Willebrand Factor

Chair:David Lillicrap
Co-Chairs:
Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Jereon Eikenboom, Emmanuel Favaloro, Anne Goodeve, Bernhard Lammle, Reinhard Schneppenheim

Anthony R. Hubbard, Michelle Hamill, Malinee Beeharry, Sally Bevan, Alan B. HeathM Shima, S Duff, M Boylan, K Sukhu, P Giangrande, S Cinotti, R Bader, C Watson, E Duncan, B Kerbl, K Friedman, J Endres, G Riera, C Eby, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, B Woodhams, M Wolf, A Lichte, J Patzke, M Timme, P Turecek, H Gritsch, C Andreini, E J Favaloro, S Rosén, A Hunfeld, J Fötisch, A Schroda, R Nawroth, D Elmlinger, K Trumbull, M Blum, J Amiral, B Samor, S Bevan, M Beeharry, M Bono, J C J Eikenboom, C A Ludlam, L Germain, S Kitchen, K Goodfellow, K Pock, A Federici, M T Canciani, A Riddell, J Conkie, G Hickman, S Berrier, C Caron, M Telesca, C M Eckmann, G Longin, P Gärtner, G Rautmann, C Raphalen, D Krause, A Blande

2009

Concentrate Standards

2nd IS Antithrombin, concentrate (96/520)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Takehiko Koide
Co-chairs:Martine. Aiach, R.M. Bertina, Frank C Church, Born Dahlbäck), Hisao Kato, David Lane

Elaine Gray (Haematology); Dawn Walker, Alan Heath (Informatics Laboratory)L Engman, H Lang, J-D Schreiber, C Mazurier, G E C Sims, G H Kurt, J Dodt, H Eran, H G Müller, S Mizusawa, K Vora, C Yee, N-E Andersson, O Santaeularia, H Tanaka, C Alonso, A Chiodo, B Whittaker, R J Mattaliano, S Thomas, S Margetts, A Wozniak

1997

3rd IS for Antithrombin, concentrate (06/166)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna

Elaine Gray, John Hogwood, Matthew Brierley, Peter RigsbyAndrea Lichte, Catherine Michalski, Celia Monnier, David Gambelli, Denise Foulon, Eva Sandberg, Guy Rautmann, Holger Blessing, J M Rentenaar, John Hogwood, Jerry Grandoni, Koen van der Drift, Lu Liu Mandy Blande, Manuela Leitner, Peter Gärtner, Raffaella Sardelli, Rolf Hovik, Silva Bergqvist, Steve Kitchen, Peter Cooper, Susanne Breitner-Ruddock

2007

1st International Standard for C-1 Inhibitor, Concentrate (08/256)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment

Chair:Thomas Renne
Co-chairs: David Gailani, Keith McCrae

Craig Thelwell, Peter Rigsby, Colin Longstaff

S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz

2010

3rd IS Factors II, X, concentrate (98/590)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier,Rainer Schwaab, Akira Yoshioka

Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory)K Mertens, R Parkinson, A Chiodo, J Brandt, A Gaillandre, L Musmanno, H G Müller, R Cooper, G E C Sims, S Lei, L Engman, R Kotitschke, U Kukral, N H Mateu, J Dodt, R Iampietro

1999

1st IS Factor VII, concentrate (97/592)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Ian R Peake, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka

Anthony R Hubbard, Trevor W Barrowcliffe (Haematology); Peter Rigsby (Informatics Laboratory)F E Preston, S Kitchen, N-E Andersson, D Howarth, A Gaillandre, A R Hubbard, P M Mannucci, R Bader, G E C Sims, B Lambrecht, K Mertens, R Parkinson, V Hahn, R Kotitschke, H Lang, J-D Schreiber, J Römisch, S C Cheung, C Michalski

1998

1st IS Factor VIIa, concentrate (89/688)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Predictive Variables

Chair:Gordon Lowe
Co-chairs:J Andrew Davies, Anders Hamsten, Mae Hultin, Kenneth K Wu

Anthony R Hubbard (Haematology)M J Larrieu, Y Laurian, G E C Sims, A Gaillandre, A R Hubbard, Y Stirling, J K Jacobsen, F Nielsen, A Oates, S Kitchen, C Michalski, H-G Muller, S Lees, H Lang, S Rosen, P M Mannucci, E Niday

1993

7th IS Factor VIII, concentrate (99/678)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Donna DiMichele
Co-chairs:Christine Lee, Koen Mertens, Johannes Oldenburg, HM van den Berg, Alok Srivastava, Jean-Marie Saint-Remy

Nancy Kirschbaum, Laura Wood, P Lachenbruch, Mark Weinstein (FDA/CBER); Karl-Heinz Buccheit, Jean-Marc Spieser, Arnold Daas (EDQM)Sanj Raut, Sally Bevan, Anthony R Hubbard, Trevor Barrowcliffe (Haematology); Dawn Sands (Informatics Laboratory)ME Albertengo, LM Olivia, B Cuthbertson, C Alonso, A Gaillandre, C. Michalski, D Baker, M Alai, N Hosta, D Baker, G Jacoby, AR Hubbard, D Baker, R Kwok, Y Katsubayashi, F Brosstad, R Kleszynski, G Carlin, R Kotitschke, U Kukral, T Najdovski, D Liu, O Shen, Y Ren, U Oswaldsson, C Loh, R Parkinson, K Mertens, G Rautmann, L Mouillot, L Regan, N Mondelo, E Piccinni, M Saenger, L Musmanno, E Sandberg, R. Sardelli, I Altieri, M Orlando, M Weinstein, L Wood, J-D Schreiber, WL Wilson, GEC Sims, F Yeganeh, A Stierle, M Taneichi, P Turecek, E Vahtera

2003

8th IS Factor VIII, concentrate (07/350)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Alok Srivastava
Co-Chairs:
Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham

Sanj Raut, Sarah Daniels, Alan HeathC Alonso, A Auer, A Banfi, S Hafner, N Kerestes, A Blande, H Blessing, R Paul, C-P Lin, D-Y Wang, Y-C Yang, B-H Chung, M-C Ho, H Chong, D D Huang, R Belcourt, D Elmlinger, M Nuss, D Gambelli, E Cini, P Gärtner, E Helgeson, N Khabbaz, T Allyn, N Hosta, A Hunfeld, R Näther, R Nawrot, L Inder, M Jankowski, S Weston, K Kamimura, M Kjalke, A Danielsen, L Odborg, M Leerabhandh, M Leitner, C Loh, L Liu, C Michalski, L Mouillot, V Lievre, L M Oliva, C LV Maria, M A Nunez, P Aprea, K Pock, M Stadler, J K Rasmussen, F Silva, S Raut, S Daniels, S Bevan, G Rautmann, C Raphalen, S Rosén, P Rosén, E Sandberg, R Sardelli, A da Silva, L Soares, C Figueiredo, L Ventura, M Taneichi, P Turecek, H Gritsch, Y Watanabe, J Weinberger, D Krause, M Wermeille, J-P Chessa, L Wong, B Badiei, M Alai, Y Wang, L Wood, T Lee

2009

3rd IS Factor IX, concentrate (96/854)

Subcommittee

Working Party

NIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Ian Peake
Co-chairs:Ernest Briët, Jørgen Ingerslev, Carol Kasper, Christopher Prowse, Yvette Sultan

No formal WP.
Key collaborators: Mark Weinstein, Thomas J Lynch (CBER)
Trevor Barrowcliffe (Haematology); Joanna Macnab (Informatics Laboratory)B Cuthbertson, R Kleszynski, A Chiodo, A Farrugia, A Beck, J Brandt, H-G Müller, G E C Sims, R Kotitschke, K Mertens, A Gaillandre, C Mazurier, C Alonso, F Balstrup, E Vahtera, L Mouillot, H Lang, O Santaeularia, Y Miura, J Torres, R Parkinson, M Weinstein, R Schütz, G Tin, U Oswaldsson, J F Wright, A R Hubbard, T Murozuka, P Jongen, E Kung, E Sandberg, W Skare, W Wilson, H Windemann, T Montag-Lessing, G H Kurt

1996

1st IS Factor IXa, concentrate (97/562)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Factor VIII and IX

Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka

Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory)H König, GEC Sims, B Letwin, O Drummond, K Mertens, C Michalski, L Engman, LJY Ho, R Iampietro, S Thomas

1999

1st IS Fibrinogen, concentrate (98/614)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinogen

Chair:Susan T Lord
Co-chairs:Michio Matsuda, Ron McIntosh, Michael W Mosesson, Willem Nieuwenhuizen

Trevor Barrowcliffe, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)S Cheung, L Wood, M MacPhee, J T Lathrop, L Jacobs, U Kukral, H Metzner, S Herring, J Morris, J-D Schreiber, B Spitzer-Sonnleitner, P Feldman, S Kingsland, R Talbot, C Backhouse, N Goss, K Almbanis, F Hawkins, D Josic, W Gehringer, P Bishop, K B Lewis, C Fukaya, L Bar, L Lukovenkou, E Feller, R Robson, R Cooper, H Duerr, J P Davis, H Kaetsu, K Odo, C M Whitton

2000

1st IS Protein C, concentrate (04/252)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna

Elaine Gray, William Pickering, Peter RigsbyJean Amiral, Eugenia Biguzzi, Daniela Asti, Peter Baker, Paul Braun, S Berrier, C Bisson, Peter Gärtner, Marilyn Johnston, Mrs Joanne McGrath, Barbara Kerbl, Steven Kitchen, Peter Cooper, Chong Loh, Matt Harvey, Catherine Michalski, Sandy Morrison, Ingrid Pabinger-Fasching, William Pickering, Miriam Ramondetta, Luigi Leo, Jeannette Rentenaar, Cheng-Hock Toh, Alan Smith, Kathleen Trumbull, Barbara Phillips, Barry Woodhams, Renata Zadro

2007

2nd IS Thrombin (01/580)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Fibrinogen

Chair:Susan T Lord
Co-chairs:Jaap Koopman, Ron McIntosh, Nicodemo Weinstock

No formal WP.
Key collaborators:
Andrew Chang, Tomothy Lee (CBER/FDA)
Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)R Cooper, M Knorst, R Kotischke, W Hong, E Sandberg, M E Albertengo, L Oliva, C Meuller, J Wang, R Sardelli, I Altieri, C Hardway, H-F Cheng, S M-C Ho, I Bravo, U Oswaldsson, M Saenger, V Gatzigiannis, C K Lee, A Terrab, J Rosser, T Najdovski, P Vanschonbeek, H Kaetsu, C Whitton, Q Shen, U Unkelbach, U Kukral, P Gaertner, J D Schreiber, W Jaklitsch

2003

1st IS von Willebrand Factor, concentrate (00/514)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
von Willebrand Factor

Chair:Robert R Montgomery
Co-chairs:Jeroen Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, Claudine Mazurier, Jacob H Rand, Francesco. Rodeghiero

No formal WP.
Key collaborators: Andrew C Chang (CBER/FDA, USA), Claudine Mazurier (LFB, France)
Anthony R Hubbard (Haematology);Dawn Sands (Informatics Laboratory)C Loh, A Farrugia, J Kanellos, R Sardelli, J Weinberger, D Gambelli, G E C Sims, U Kukral, M Stadler, W K Stevens, A Riddell, C Lee, C Michalski, M T Canciani, A B Federici, J-D Schreiber, C Miller, C Mazurier, B Samor, K Friedman, R Montgomery, B Neugebauer, E Favaloro, P Turecek, M G Riera, H-G Müller, A C Chang, A R Hubbard, L J Weller, J Lusher, C Wiseman, G Mohn, F Rodeghiero, A Tosetto

2001

2nd IS von Willebrand Factor, concentrate (09/182)

SubcommitteeNIBSC PersonnelParticipantsWHO
Establishment
von Willebrand Factor

Chair:Jeroen EikenboomCo-chairmen:Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Emmanuel J Favaloro, Anne Goodeve, Bernhard Lämmle, David Lillicrap, Reinhard Schneppenheim

Anthony R Hubbard, Michelle L Hamill, Malinee Beeharry, Sally A Bevan and Alan B HeathM Shima, K Sukhu, D Keeling, E Duncan, J Endres, K Friedman, S Langlet, S Duff, M Boylan, T Willis, K C Matthews, C Watson, B Hopkins, B Kerbl, M G Riera, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, P Turecek, H Gritsch, E J Favaloro, A Hunfeld, Ms Schroda, Ms Sächerl, Ms Näther, K Trumbull, W Olend, C Michalski, B Samor, E Lefebvre, M Beeharry, S Bevan, C A Ludlam, L Germain, S Kitchen, A Bowyer, B Sampson, A Riddell, S Berrier, C Bisson, M Weinstein, D Lebel, C Caron, D Lillicrap, A Tuttle, C M Eckmann, J Rentenaar, P Gärtner, D Gambelli, N Lucchesi, J Weinberger, D Krause, S Nair, A Srivastava, J Amiral, M Bono, H C J Eikenboom, C van Rijn, M Stadler, F Peyvandi, M T Canciani, A Blande, H Blessing, P Bayer, C Burgess, P Credland, J Patzke, A Jones, N Hosta, S Gigan, V Lievre, H Chong

2010

Fibrinolytics and Anticoagulants etc.

1st IS Beta thromboglobulin, purified, human (83/501)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Platelets

Chair:Barry S Coller
Co-chairs:Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith

Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics laboratory)A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub

1984

1st International Genetic Reference Panel Factor V Leiden, Human gDNA (04/224)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Frank C Church
Co-chairs:Francesco Bernardi, Elaine Gray, Craig J. Jackson, David Lane,Koji Suzuki

No formal WP.
Key collaborators:
UK NEQAS (Blood Coagulation)
Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI)N Akar, F Araujo, Y Ayob, F Bernardi, C Blackie, D J Bowen, S Bowley, S Brooks, D Perry, P Carr, R Das, T Cumming, S Keeney, L Emiliusen, J Heit, A D Gupta, W Erber, M S Enayat, M S Figueiredo, J Farrugia, A Copplestone, G Gibbs, S V Davies, O Gerach-Jelaushun, S Kalsheker, I Hrachovinova, E Lindhoff-Last, S Kitchen, S Cooper, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, M Morrison, J Rosing, E Castoldi, J C Osselaer, R Saxena, A Smith, M Waite, G Standen, T Clench, J Thumpston, H Vetr, M A Vasef, G Willis, H White, R Zadro, P Wright, D Keeling, J Zehnder

2004

1st International Genetic Reference Panel for Prothrombin Mutation (G20210A), Human gDNA (05/130)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Plasma Coagulation Inhibitors

Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Frank C Church, Craig J. Jackson, David Lane, Koji Suzuki, Herbert C Whinna

No formal WP.
Key collaborators:
UK NEQAS (Blood Coagulation)
Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI)N Akar, F Araujo, B Auguston, J Prior, C Ayuso, F Bernardi, C Blackie, D J Bowen, S Brooks, D Perry, P Carroll, J-M Costa, R Das, T Cumming, S Keeney, B Donahue, G Wissel, M S Enayat, J Farrugia, T Fidalgo, M S Figueiredo, O Garach-Jehoshua, B Gilfix, M Hawkins, I Hrachovinova, I Jarvela, A Orpana, S Kadkol, S Kalsheker, M Kambouris, S Kitchen, S Cooper, C Klein, J Marki-Zay, E Koay, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, A Nejad, S Pena, R Sturzeneker, J Rosing, E Castoldi, R Saxena, A Smith, D Snell, G Standen, T Clench, A Valiente, H Vetr, G Willis, H White, V Durston, K Smith, R Zadro, P Wright, D Keeling, R Zadro

2005

5th IS Heparin, porcine mucosal (97/578)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Control of Anticoagulation

Chair:Francis E Preston
Co-chairs:Giancarlo Agnelli, Trevor W Barrowcliffe, A.M.H.P. van den Besselaar, Bernard Boneu, Alan R Giles, Leon Poller, Armando Tripodi

Elaine Gray, Trevor Barrowcliffe (Haematology); Dawn Walker (Informatics Laboratory); Barbara Mulloy (Laboratory for Molecular Structure)G van Dedem, P J Morris, K B Johansen, J F Branellec, D Williamson, T Yin, R Porta, P Shaklee, S Gonella, P Shepherd, E Coyne, F C Arntzen, C Alonso, M E Albertengo, L Best, F Rosenberg, J-M Spieser, T Tanimoto, A Beck, C L van Gorp, J Fareed, S Thomas, R Iampietro, E Sandberg, J Flensburg

1998

2nd IS Low Molecular Weight Heparin (01/608)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Control of Anticoagulation

Chair:Mike Greaves
Co-chairs:Henri Bounameaux, Job Harenberg, Clive Kearon,
Michael Laposata, Frits R Rosendaal, Sam Schulman,
Armando Tripodi, A.M.H.P. van den Besselaar

No formal WP.
Key collaborator:
Marie-Emmanuelle Behr-Gross (EDQM)
Elaine Gray (Haematology); Peter Rigsby (Informatics Laboratory)B Parma, P N Shaklee, G Rautmann, G Cozic, H Nagel, M Schroder, K MacKinnon, M Kovacs, V Dupont, C Alonso, B van Genugten, J Fareed, J Harenberg, E Sandberg, M E Albertengo, L Oliva, M Esnaola, C Loh, J J Descombe, R Domanig, J I Weitz, A C Fylling, Y Gourmelin, F Lackner, J Tapon-Bretaudiere, J Dufaux, J Dayan-Kenigsberg, S Kitchen, F C Arntzen, K Erlandsson-Persson, M L Wiesel, S Thomas, F Nicham, E Holmer

2003

6th IS Unfractionated Heparin (WHO/BS/09.2124)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Control of Anticoagulation

Chair:Trevor Baglin
Co-chairs:Walter Ageno, Job Harenberg, Clive Kearon, Aharon Lubetsky, John
Olson, Gualtiero Palareti, Sam Schulman, AMHP van den Besselaar

Elaine Gray, John Hogwood, Peter Rigsby, Barbara Mulloy, Anita Y Szajek, Michael R Ambrose, Fabian Jameison, Walter Hauck, Tina S MorrisGinés Diaz and Maria Mercedes Lopez, Peter Gärtner, Patrick Shaklee, Jesus Cabañas, Maik Gehrke and Gerrit Oldekamp, Eva Sandberg, François Nicham and Nathalie Barat, Guy Rautmann, C.S. Venkatesan, Dean Smith and Hing Chong, Luis Soares, Ljiljana Kudra and Dženita Softic, Donata Bensi, Pilar Carrasco, Bjørn Fehrmann, Oliver Rädler, Fan Huihong and Li Jing, John Hogwood, Hinrich Nagel, Peter Bruegger, Karin Stoll- Rubin, Susanne Alban, Thomas Freudemann, Cécile Auguste and Céline Houiste, Hester Hasper, Hitendra Mehta and Anisha Akula, Wolfgang Klein, Stephanie Berrier, Roger Meier, Barbara Kerbl, Toshimi Murai and Yukari Nakagawa, Chong Loh and Allison Jones, Sérgio Luiz Dalmora, Michael Ambrose and Jeanne Fringer,

2009

3rd IS Plasmin (97/536)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Nuala A Booth
Co-chairs:Paul J Declerck, Cornelis Kluft,
Osamu Matsuo

Patrick J Gaffney, Tracy A Edgell, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)J Jespersen, R Lijnen, E Ersdal, T A Edgell, B Binder, V Sarin

1998

IS Plasminogen activator inhibitor - 1, plasma, human (92/654)

SubcommitteeWorking PartyNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Cornelis Kluft
Co-chairs:Dudley Strickland, Bernd Binder, Jorgen Gram

Key collaborator:
Paul Declerck (Leuven)
Patrick J Gaffney, Tracy A Edgell(Haematology)B Binder, J Jespersen, S Rosen, P Declerck, T Edgell, M Ranby, C Kluft, N A Booth

1995

1st IS Platelet Factor 4 (83/505)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Platelets

Chair:Barry S Coller
Co-chairs:Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith

Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics Laboratory)A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub

1984

3rd IS Streptokinase (00/464)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Paul J Declerck
Co-chairs:Nuala A Booth, Carl-Erik H Dempfle, Osamu Matsuo, Michael Nesheim

Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)E Sandberg, S Agerholm, J Jespersen, J Sidelmann, E Anglés-Cano, V Bottiger, M Knorst, K S Chief, M Orlando, R Sardelli, I Altieri, E Charton, A E Sterin Prync, C M Buslje, S M Dabsys, T Urano, H Wu, M Xu, M Zhang, H R Lijnen, C Whitton, C Longstaff, C L Reed, A V Sriram, D Vijayarangam, S Pullamsetti, Y Martinez

2001

2nd IS Streptodornase (WHO/BS/09.2112)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Colin Longstaff
Co-chairs:Carl-Erik Dempfle, Ann Gils, Dirk Hendriks, Osamu Matsuo, Michael Nesheim, Tetsumei Urano

Colin Longstaff , Peter RigsbyReinhard Paul, Mabel Izquierdo Lopez, Jyoti Patel, Hee-Sung Kim, Seungno Yang, V.K.Srinivas

2009

3rd IS Tissue Plasminogen Activator, human, recombinant (98/714)

SubcommitteeNIBSC PersonnelParticipantsWHO Establishment
Fibrinolysis

Chair:Nuala A Booth
Co-chairs:Paul J Declerck, Carl-Erik H Dempfle, Osamu Matsuo

Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)A Takada, B R Binder, A Meunier, S Bassarab, A Farrugia, A Mackerras, J Jespersen, N Sakuragawa, N A Booth, T Sullivan, D C Rijken, C Longstaff, S Rosen, C Whitton, E Anglés-Cano

2000

IS High Molecular Weight Urokinase (87/594)

SubcommitteeNIBSC Personnel

Participants

WHO Establishment
Fibrinolysis

Chair:David J Loskutoff
Co-chairs:R.S. Schleef, M Egbert Kruithof, H. Pannekoek, Patrick Gaffney, David C Stump

Patrick J Gaffney (Haematology);Alan Heath (Informatics Laboratory)P Sackett, E K O Kruithof, H R Lijnen, M Samama, L Mahlen, D Beebe, A Metz, J B Pring, W A Gunzler, M Nobuhara, R Kussat

1989


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