The SSC is grateful for the generous participation of many members in the generation of good standards data, which underpins so much of the work of the SSC and ISTH. We have created this record for standards adopted by WHO/ECBS in recent years as a way of acknowledging the input of time, expertise and reagents. We may be missing information for some older standards. Please advise Cary Clark (headquarters@isth.org) of any additional information. Plasma Standards • Concentrate Standards • Fibrinolytics and Anticoagulants Plasma Standards 2nd International Standard for Antithrombin, plasma (93/768) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Sadaaki Iwanaga
Co-chairs:R.M. Bertina, Born Dahlbäck, Takehiko Koide, David Lane | Trevor Barrowcliffe, Jane Watton (Haematology); Alan Heath (Informatics Laboratory) | K Benford, E Briet, A-M Fischer, D J Warnuek, S Fedy, J Conard, J Fareed, M Johnston, J Maynard, P Cooper, F E Preston, H P Beeser, H Ridgeway, J Lloyd, E Duncan, J Watton, T W Barrowcliffe, A Tripodi, J Brandt, C Wagner, A-S Carlstrom, U Abildgaard, J Arnout | 1994 |
3rd International Standard for Antithrombin, plasma | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Herbert C Whinna
Co-chairs:Francesco Bernardi, Elaine Gray, Tilman Hackeng, Steven Kitchen, Richard Marlar, P Meijer, Laurent Mosnier | John Hogwood, Michelle Hamill, Peter Rigsby, Elaine Gray | D Adcock, L Desjardin, J Amiral, P Baker, N Barat, F Nicham, M Bono, C Caron, G Hickman, J Conkie, P Cooper,
E Biguzzi, D Asti, D Foulon, L Germain, C Ludlam, J Hogwood, H Hoogendoorn,
A Jones, T Kerim, B Kerbl, A Lichte, R Luddington, S Nair, A Srivastava, J Rentenaar, A Riddell, J Jespersen, J Sidelmann, K Trumbull, K Villadsen, A-M Hvas, Renata Zadro | 2010 |
1st International Standard for C-1 Inhibitor, Plasma (08/262) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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Chair:Thomas Renne
Co-chairs: David Gailani, Keith McCrae | Craig Thelwell, Peter Rigsby, Colin Longstaff | S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz | 2010 |
3rd International Standard Factors II, VII, IX, X, plasma (99/826) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Donna DiMichele
Co-Chairs:Jørgen Ingerslev, Christine Lee, Koen. Mertens, Claude G Negrier, Johannes Oldenburg,Dorothea Scandella, Akira Yoshioka | Elaine Gray, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory) | R Bader, J Gillissen, P Braun, C Lessard, M Seidler, K Denson, D Howarth, F Ofosu, F van der Meer, R Parkinson, S Lees, S Kitchen, B Sampson, J Lloyd, J Ingerslev, H Ridgeway, L Lottin, M Robers, H Lehmann, L Weller, R Iampetrio, S Thomas | 2001 |
4th International Standard Factors II, VII, IX, X, plasma (09/172) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Alok Srivastava
Co-Chairs: Jan Astermark, Kathelijn Fischer, Charles Hay, Claude Negrier, Johannes Oldenburg, Flora Peyvandi, Edward Tuddenham, Leonard Valentino | Elaine Gray, Helen Barson, Jason Hockley, Peter Rigsby | R Zadro, J.M.Rentenaar, K Sukhu, J Jespersen, J Sidelmann, S Nair, M Timme, R Luddington, M Boylan, R Bader, C Caron, K Villadsen, A-M Hvas, C Ludlam, L Germain, J Amiral, D Adcock, L Desjardin, A Riddell, M Bono, K Trumbull, W Olend, B Kerbl, D Foulon, H Hoogendoorn, J McGrath, H Barson, M Beeharry, N Barat, F Nicham, J Conkie, G Hickman, S Rosen, A Bowyer, L Saminaden, J Gillissen, K Bradley, C Loh, A Jones, T kerim, N Lucchesi, D Gambelli | 2010 |
1st International Standard for Blood Coagulation Factor V in Plasma, Human (03/116) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and Factor IX Chair:Koen Mertens
Co-Chairs:Joan Cox Gill, Christine Lee, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg | Anthony R. Hubbard (Haematology); Suzanne Johnes (Informatics Laboratory) | A Hunfeld, J M Rentenaar, R Bader, S Kitchen, A Bowyer, K Trumbull, M Shima, C Lee, A Riddell, C Caron, H Metzner, F Nicham, J Weinberger, B Kerbl, A Hubbard, L J Weller, S Berrier, R Veinotte, S Duff, S Rosen, C Loh, P Giangrande, K Sukhu, J V Lloyd, E Duncan, A Tosetto, A Cappelletti, JCJ Eikenboom, D Harz | 2005 |
5th International Standard for Blood Coagulation Factor VIII and Von Willebrand Factor in Plasma, Human (02/150) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and Factor IX Chair:Donna DiMichele
Co-Chairs:Christine Lee, Koen Mertens, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg Von Willebrand Factor Chair:Robert R Montgomery
Co-Chairs:Giancarlo Castaman, Jeroen C.J. Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, David Lillicrap, Claudine Mazurier | Anthony R Hubbard (Haematology), Alan B Heath (Informatics Laboratory) | A Yoshioka, K Sukhu, P Giangrande, R Bader, J V Lloyd, J Endres, C Eby, R Kotitschke, S Joyon, H Metzner, C andreini, S Rosen, S Duff, S Cinotti, C Watson, M Griffiths, M G Riera, M Ledford, F Rodeghiero A Tosetto, J M Lusher, C Wiseman, M Wolf, P Turecek, E Favaloro, A Hunfeld, K Trumbull, C Mazurier, B Samor, M Knorst, S Bevan, L Weller, J Patzke, C A Ludlam, C Michalski, D A Triplett, S Kitchen, B Sampson, C A Lee, A Riddell, M Grimaux, J Ingerslev, C Caron, C M Eckmann | 2003 |
1st International Standard for Blood Coagulation Factor XI in Plasma, Human (04/102) and Calibration of Blood Coagulation Factor XI in SSC Secondary Plasma Standard Lot#3 | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Kallikrein-Kinin System Chair:Keith R McCrai
Co-Chairs:Raul A DeLa Cadena, David Gailani Michael J Gallimore, Hidehiko Saito, Alvin H Schmaier Working Group on Plasma Coagulation Standards Chair:Jane Lenahan | Elaine Gray, Stephen Thomas (Haematology); Peter Rigsby (Informatics Laboratory) | R Bader, A Bianchi Bonomi, A Bellisario, A Starace, S Antimo, A Birchall, A Abrahams, P Bolton-Maggs, D Shanks, S Duff, M Boylan, E Duncan, C Casey, D Elminger, T Fanella, D Gailani, G Baxter, J Gillissen, K Bradley, P Harper, L Glogoski, A Hunfeld, S Rosenkranz, L Ivey, W Jones, S Harris, B Kerbl, S Kitchen, A Bowyer, D Lawson, P Braun, L Lim, M Taylor, I Mackie, A Lawrie, K Mertens, C Eckmann, G Rautmann, U Selgsohn, A Zivelin, I Tamarin, K Sukhu, S Thomas, K Trumbull, B Phillips, J Weinberger, D Krause, L Weller | Oct. 2005 |
1st International Standard for Factor XIII, Plasma (02/206) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Factor XIII Chairman: Robert Ariens
Co-Chairs:Paul Bishop, Akitada Ichinose | Factor XIII Standardization WP(Akitada Ichinose,Chair, Trevor Barrowcliffe, Laszlo Muszbek, Rainer Seitz, Robert. Ariens) | Sanj Raut, Elizabeth Merton, Trevor Barrowcliffe (Haematology);Peter Rigsby, Daniella Belgrave (Informatics Laboratory) | M. Arai, R. Ariens, M. Boothby, N. Booth, N. Moore, A. Birchall, G. Castaman, A Tosetto, C. Caron, M. Dreyfus, M. Hanss, A. Hunfeld, H.I. Hassouna, A. Inbal, A. Ichinose, S.M. Kang, H.P. Kohler, V. Schroeder, K. Christian, S. Kingsland, M.Knorst, D.S. Lee, J.C.M. Meijers, H. Metzner, L. Muszbek, B. Polack, S Raut, E. Merton, K. Sukhu, M. Wilmer, K. Rudin, M. Wilkens | 2004 |
2nd International Standard for Fibrinogen, plasma (98/612) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Fibrinogen Chair:Michael W Mosesson
Co-chairs:Frank Brosstad, Michio Matsuda, Willem Nieuwenhuizen, Ron McIntosh | Patrick J Gaffney, Colin M Whitton, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory) | E Bovill, H Lang, J-D Schreiber, D Howarth, W Nieuwenhuizen, S Kitchen, I J Mackie, A S Lawrie, J Conkie, R Bader, J A Ruiz, M Boldt, J L Martinoli, C Whitton | 1999 |
1st International Standard for Protein C, Plasma, Human (86/622) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Protein C and S Chair:RM Bertina
Co-Chairs:RR Montgomery, JH Griffin, JP Miletich, AR Hubbard, I Pabinger, AW Broekmans | Anthony R Hubbard, Duncan P Thomas (Haematology) | U Becker, RM Bertina, B Chambrette, A Dessauer, D Green, JH Griffin, AR Hubbard, H Lang, MJ Larrieu, PM Mannucci, RA Marlar, K Mertens, S Rosen, N Sala, I Scharrer, H Vinazzer, S Wasi | 1987 |
2nd International Standard for Protein C, plasma (02/342) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Elaine Gray
Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna | Elaine Gray, William Pickering (Haemostasis); Peter Rigsby (Informatics Laboratory); | J Amiral, E Biguzzi, D Asti, P Baker, P Braun, S Berrier, C Bisson, P Gärtner, M Johnston, J McGrath, B Kerbl, S Kitchen, P Cooper, C Loh, M Harvey, C Michalski, S Morriso, I Pabinger-Fasching, W Pickering, M Ramondetta, L Leo, J Rentenaar, C-H Toh, A Smith, K Trumbull, B Phillips, B Woodhams, R Zadro | 2006 |
1st International Standard for Protein S, Plasma, Human (93/590) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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Chair:Takehiko Koide
Co-Chairs:RM Bertina, Bjorn Dahlback, Sadaaki Iwanaga, David Lane | Anthony R Hubbard (Haematology) | AM Burn, F Franchi, A Tosetto, RM Bertina, J Amiral, I Walker, J Conkie, J J Michiels, HHDM van Vliet, I Pabinger, B Woodhams, M Burgess-Wilson, H Lang, B Dahlback, R A Marlar, D Meyer, F E Preston, P Cooper, A R Hubbard, A Lawrie | 1995 |
2nd International Standard for Protein S, plasma (03/228) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Elaine Gray
Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna | Anthony R Hubbard, Lynne Weller (Haemostasis); Alan B Heath (Informatics Laboratory) | E Biguzzi, D Asti, P Baker, M Stegnar, A Smith, M Johnston, B Kerbl, M Smith, A R Hubbard, L J Weller, J C J Eikenboom, R Marlar, I Pabinger, R Zadro, K Mertens, J Rentenaar, J Patzke, D D Castellone, S Berrier, M-O Couche, S Lees, P Cooper, S Kitchen, J Conkie, C Legnani, G Palareti | 2006 |
1st IS for Tissue Plasminogen Activator (tPA) Antigen, Plasma (94/730) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Fibrinolysis Chair:Colin Longstaff
Co-Chairs:Carl-Erik H. Dempfle, Ann Gils, D Hendriks, Osamu Matsuo, Michael E. Nesheim | Colin Whitton, Peter Rigsby, Colin Longstaff | Yves Gourmelin, Stéphanie Berrier, Barbara Kerbl, Jean Amiral, Ann Rumley/Gordon Lowe, Norma Moore/Nuala Booth, Tetsumei Urano, Pamela Dawson, Colin Whitton, Annika Sköld, Renate Beckmann, Paul Declerck, J.C.M. Meijers | 2007 |
4th International Standard for Thromboplastin, Rabbit, Plain | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Control of Anticoagulation Chair:Sam Schulman
Co-Chairs:Mike Greaves, Job Harenberg, Clive Kearon, Michael Laposata, John Olson, Gualtiero Palareti, F.R. Rosendaal, AMHP van den Besselaar |
| P Angchaisuksiri, K Aryurachai, M Borrell, V Chantarangkul, A Tripodi, K Denson, T Gago, P Herbel, A Jünschke, W Plesch, M Johnston, S Kitchen, C Legnani, T Lindahl, R Manning, M Martinuzzo, D Mezzano, N Opartkiattikul, K Overgaard, J Jespersen, V Pengo, M Persson, A Hillarp, R Redaelli, F Baudo, P Rojnuckarin, B Akkawat, E Witteveen, AMHP van den Besselaar, H Wada | 2005 |
6th IS Factor VIII/von Willebrand factor Plasma (WHO/BS/09.2116) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX< Chair:Alok Srivastava
Co-Chairs:Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham von Willebrand Factor Chair:David Lillicrap
Co-Chairs:Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Jereon Eikenboom, Emmanuel Favaloro, Anne Goodeve, Bernhard Lammle, Reinhard Schneppenheim | Anthony R. Hubbard, Michelle Hamill, Malinee Beeharry, Sally Bevan, Alan B. Heath | M Shima, S Duff, M Boylan, K Sukhu, P Giangrande, S Cinotti, R Bader, C Watson, E Duncan, B Kerbl, K Friedman, J Endres, G Riera, C Eby, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, B Woodhams, M Wolf, A Lichte, J Patzke, M Timme, P Turecek, H Gritsch, C Andreini, E J Favaloro, S Rosén, A Hunfeld, J Fötisch, A Schroda, R Nawroth, D Elmlinger, K Trumbull, M Blum, J Amiral, B Samor, S Bevan, M Beeharry, M Bono, J C J Eikenboom, C A Ludlam, L Germain, S Kitchen, K Goodfellow, K Pock, A Federici, M T Canciani, A Riddell, J Conkie, G Hickman, S Berrier, C Caron, M Telesca, C M Eckmann, G Longin, P Gärtner, G Rautmann, C Raphalen, D Krause, A Blande | 2009 |
Concentrate Standards 2nd IS Antithrombin, concentrate (96/520) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Plasma Coagulation Inhibitors Chair:Takehiko Koide
Co-chairs:Martine. Aiach, R.M. Bertina, Frank C Church, Born Dahlbäck), Hisao Kato, David Lane | Elaine Gray (Haematology); Dawn Walker, Alan Heath (Informatics Laboratory) | L Engman, H Lang, J-D Schreiber, C Mazurier, G E C Sims, G H Kurt, J Dodt, H Eran, H G Müller, S Mizusawa, K Vora, C Yee, N-E Andersson, O Santaeularia, H Tanaka, C Alonso, A Chiodo, B Whittaker, R J Mattaliano, S Thomas, S Margetts, A Wozniak | 1997 |
3rd IS for Antithrombin, concentrate (06/166) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna | Elaine Gray, John Hogwood, Matthew Brierley, Peter Rigsby | Andrea Lichte, Catherine Michalski, Celia Monnier, David Gambelli, Denise Foulon, Eva Sandberg, Guy Rautmann, Holger Blessing, J M Rentenaar, John Hogwood, Jerry Grandoni, Koen van der Drift, Lu Liu Mandy Blande, Manuela Leitner, Peter Gärtner, Raffaella Sardelli, Rolf Hovik, Silva Bergqvist, Steve Kitchen, Peter Cooper, Susanne Breitner-Ruddock | 2007 |
1st International Standard for C-1 Inhibitor, Concentrate (08/256) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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Chair:Thomas Renne
Co-chairs: David Gailani, Keith McCrae | Craig Thelwell, Peter Rigsby, Colin Longstaff | S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz | 2010 |
3rd IS Factors II, X, concentrate (98/590) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier,Rainer Schwaab, Akira Yoshioka | Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory) | K Mertens, R Parkinson, A Chiodo, J Brandt, A Gaillandre, L Musmanno, H G Müller, R Cooper, G E C Sims, S Lei, L Engman, R Kotitschke, U Kukral, N H Mateu, J Dodt, R Iampietro | 1999 |
1st IS Factor VII, concentrate (97/592) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Ian R Peake, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka | Anthony R Hubbard, Trevor W Barrowcliffe (Haematology); Peter Rigsby (Informatics Laboratory) | F E Preston, S Kitchen, N-E Andersson, D Howarth, A Gaillandre, A R Hubbard, P M Mannucci, R Bader, G E C Sims, B Lambrecht, K Mertens, R Parkinson, V Hahn, R Kotitschke, H Lang, J-D Schreiber, J Römisch, S C Cheung, C Michalski | 1998 |
1st IS Factor VIIa, concentrate (89/688) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Predictive Variables Chair:Gordon Lowe
Co-chairs:J Andrew Davies, Anders Hamsten, Mae Hultin, Kenneth K Wu | Anthony R Hubbard (Haematology) | M J Larrieu, Y Laurian, G E C Sims, A Gaillandre, A R Hubbard, Y Stirling, J K Jacobsen, F Nielsen, A Oates, S Kitchen, C Michalski, H-G Muller, S Lees, H Lang, S Rosen, P M Mannucci, E Niday | 1993 |
7th IS Factor VIII, concentrate (99/678) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Donna DiMichele
Co-chairs:Christine Lee, Koen Mertens, Johannes Oldenburg, HM van den Berg, Alok Srivastava, Jean-Marie Saint-Remy | Nancy Kirschbaum, Laura Wood, P Lachenbruch, Mark Weinstein (FDA/CBER); Karl-Heinz Buccheit, Jean-Marc Spieser, Arnold Daas (EDQM) | Sanj Raut, Sally Bevan, Anthony R Hubbard, Trevor Barrowcliffe (Haematology); Dawn Sands (Informatics Laboratory) | ME Albertengo, LM Olivia, B Cuthbertson, C Alonso, A Gaillandre, C. Michalski, D Baker, M Alai, N Hosta, D Baker, G Jacoby, AR Hubbard, D Baker, R Kwok, Y Katsubayashi, F Brosstad, R Kleszynski, G Carlin, R Kotitschke, U Kukral, T Najdovski, D Liu, O Shen, Y Ren, U Oswaldsson, C Loh, R Parkinson, K Mertens, G Rautmann, L Mouillot, L Regan, N Mondelo, E Piccinni, M Saenger, L Musmanno, E Sandberg, R. Sardelli, I Altieri, M Orlando, M Weinstein, L Wood, J-D Schreiber, WL Wilson, GEC Sims, F Yeganeh, A Stierle, M Taneichi, P Turecek, E Vahtera | 2003 |
8th IS Factor VIII, concentrate (07/350) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Factor VIII and IX Chair:Alok Srivastava
Co-Chairs:Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham | Sanj Raut, Sarah Daniels, Alan Heath | C Alonso, A Auer, A Banfi, S Hafner, N Kerestes, A Blande, H Blessing, R Paul, C-P Lin, D-Y Wang, Y-C Yang, B-H Chung, M-C Ho, H Chong, D D Huang, R Belcourt, D Elmlinger, M Nuss, D Gambelli, E Cini, P Gärtner, E Helgeson, N Khabbaz, T Allyn, N Hosta, A Hunfeld, R Näther, R Nawrot, L Inder, M Jankowski, S Weston, K Kamimura, M Kjalke, A Danielsen, L Odborg, M Leerabhandh, M Leitner, C Loh, L Liu, C Michalski, L Mouillot, V Lievre, L M Oliva, C LV Maria, M A Nunez, P Aprea, K Pock, M Stadler, J K Rasmussen, F Silva, S Raut, S Daniels, S Bevan, G Rautmann, C Raphalen, S Rosén, P Rosén, E Sandberg, R Sardelli, A da Silva, L Soares, C Figueiredo, L Ventura, M Taneichi, P Turecek, H Gritsch, Y Watanabe, J Weinberger, D Krause, M Wermeille, J-P Chessa, L Wong, B Badiei, M Alai, Y Wang, L Wood, T Lee | 2009 |
3rd IS Factor IX, concentrate (96/854) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Factor VIII and IX Chair:Ian Peake
Co-chairs:Ernest Briët, Jørgen Ingerslev, Carol Kasper, Christopher Prowse, Yvette Sultan | No formal WP.
Key collaborators: Mark Weinstein, Thomas J Lynch (CBER) | Trevor Barrowcliffe (Haematology); Joanna Macnab (Informatics Laboratory) | B Cuthbertson, R Kleszynski, A Chiodo, A Farrugia, A Beck, J Brandt, H-G Müller, G E C Sims, R Kotitschke, K Mertens, A Gaillandre, C Mazurier, C Alonso, F Balstrup, E Vahtera, L Mouillot, H Lang, O Santaeularia, Y Miura, J Torres, R Parkinson, M Weinstein, R Schütz, G Tin, U Oswaldsson, J F Wright, A R Hubbard, T Murozuka, P Jongen, E Kung, E Sandberg, W Skare, W Wilson, H Windemann, T Montag-Lessing, G H Kurt | 1996 |
1st IS Factor IXa, concentrate (97/562) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Factor VIII and IX Chair:Jørgen Ingerslev
Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka | Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory) | H König, GEC Sims, B Letwin, O Drummond, K Mertens, C Michalski, L Engman, LJY Ho, R Iampietro, S Thomas | 1999 |
1st IS Fibrinogen, concentrate (98/614) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Fibrinogen Chair:Susan T Lord
Co-chairs:Michio Matsuda, Ron McIntosh, Michael W Mosesson, Willem Nieuwenhuizen | Trevor Barrowcliffe, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory) | S Cheung, L Wood, M MacPhee, J T Lathrop, L Jacobs, U Kukral, H Metzner, S Herring, J Morris, J-D Schreiber, B Spitzer-Sonnleitner, P Feldman, S Kingsland, R Talbot, C Backhouse, N Goss, K Almbanis, F Hawkins, D Josic, W Gehringer, P Bishop, K B Lewis, C Fukaya, L Bar, L Lukovenkou, E Feller, R Robson, R Cooper, H Duerr, J P Davis, H Kaetsu, K Odo, C M Whitton | 2000 |
1st IS Protein C, concentrate (04/252) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Plasma Coagulation Inhibitors Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna | Elaine Gray, William Pickering, Peter Rigsby | Jean Amiral, Eugenia Biguzzi, Daniela Asti, Peter Baker, Paul Braun, S Berrier, C Bisson, Peter Gärtner, Marilyn Johnston, Mrs Joanne McGrath, Barbara Kerbl, Steven Kitchen, Peter Cooper, Chong Loh, Matt Harvey, Catherine Michalski, Sandy Morrison, Ingrid Pabinger-Fasching, William Pickering, Miriam Ramondetta, Luigi Leo, Jeannette Rentenaar, Cheng-Hock Toh, Alan Smith, Kathleen Trumbull, Barbara Phillips, Barry Woodhams, Renata Zadro | 2007 |
2nd IS Thrombin (01/580) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Fibrinogen Chair:Susan T Lord
Co-chairs:Jaap Koopman, Ron McIntosh, Nicodemo Weinstock | No formal WP.
Key collaborators:
Andrew Chang, Tomothy Lee (CBER/FDA) | Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory) | R Cooper, M Knorst, R Kotischke, W Hong, E Sandberg, M E Albertengo, L Oliva, C Meuller, J Wang, R Sardelli, I Altieri, C Hardway, H-F Cheng, S M-C Ho, I Bravo, U Oswaldsson, M Saenger, V Gatzigiannis, C K Lee, A Terrab, J Rosser, T Najdovski, P Vanschonbeek, H Kaetsu, C Whitton, Q Shen, U Unkelbach, U Kukral, P Gaertner, J D Schreiber, W Jaklitsch | 2003 |
1st IS von Willebrand Factor, concentrate (00/514) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
|---|
| von Willebrand Factor Chair:Robert R Montgomery
Co-chairs:Jeroen Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, Claudine Mazurier, Jacob H Rand, Francesco. Rodeghiero | No formal WP.
Key collaborators: Andrew C Chang (CBER/FDA, USA), Claudine Mazurier (LFB, France) | Anthony R Hubbard (Haematology);Dawn Sands (Informatics Laboratory) | C Loh, A Farrugia, J Kanellos, R Sardelli, J Weinberger, D Gambelli, G E C Sims, U Kukral, M Stadler, W K Stevens, A Riddell, C Lee, C Michalski, M T Canciani, A B Federici, J-D Schreiber, C Miller, C Mazurier, B Samor, K Friedman, R Montgomery, B Neugebauer, E Favaloro, P Turecek, M G Riera, H-G Müller, A C Chang, A R Hubbard, L J Weller, J Lusher, C Wiseman, G Mohn, F Rodeghiero, A Tosetto | 2001 |
2nd IS von Willebrand Factor, concentrate (09/182) | Subcommittee | NIBSC Personnel | Participants | WHO
Establishment |
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| von Willebrand Factor Chair:Jeroen EikenboomCo-chairmen:Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Emmanuel J Favaloro, Anne Goodeve, Bernhard Lämmle, David Lillicrap, Reinhard Schneppenheim | Anthony R Hubbard, Michelle L Hamill, Malinee Beeharry, Sally A Bevan and Alan B Heath | M Shima, K Sukhu, D Keeling, E Duncan, J Endres, K Friedman, S Langlet, S Duff, M Boylan, T Willis, K C Matthews, C Watson, B Hopkins, B Kerbl, M G Riera, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, P Turecek, H Gritsch, E J Favaloro, A Hunfeld, Ms Schroda, Ms Sächerl, Ms Näther, K Trumbull, W Olend, C Michalski, B Samor, E Lefebvre, M Beeharry, S Bevan, C A Ludlam, L Germain, S Kitchen, A Bowyer, B Sampson, A Riddell, S Berrier, C Bisson, M Weinstein, D Lebel, C Caron, D Lillicrap, A Tuttle, C M Eckmann, J Rentenaar, P Gärtner, D Gambelli, N Lucchesi, J Weinberger, D Krause, S Nair, A Srivastava, J Amiral, M Bono, H C J Eikenboom, C van Rijn, M Stadler, F Peyvandi, M T Canciani, A Blande, H Blessing, P Bayer, C Burgess, P Credland, J Patzke, A Jones, N Hosta, S Gigan, V Lievre, H Chong | 2010 |
Fibrinolytics and Anticoagulants etc. 1st IS Beta thromboglobulin, purified, human (83/501) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Platelets Chair:Barry S Coller
Co-chairs:Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith | Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics laboratory) | A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub | 1984 |
1st International Genetic Reference Panel Factor V Leiden, Human gDNA (04/224) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Frank C Church
Co-chairs:Francesco Bernardi, Elaine Gray, Craig J. Jackson, David Lane,Koji Suzuki | No formal WP.
Key collaborators:
UK NEQAS (Blood Coagulation) | Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI) | N Akar, F Araujo, Y Ayob, F Bernardi, C Blackie, D J Bowen, S Bowley, S Brooks, D Perry, P Carr, R Das, T Cumming, S Keeney, L Emiliusen, J Heit, A D Gupta, W Erber, M S Enayat, M S Figueiredo, J Farrugia, A Copplestone, G Gibbs, S V Davies, O Gerach-Jelaushun, S Kalsheker, I Hrachovinova, E Lindhoff-Last, S Kitchen, S Cooper, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, M Morrison, J Rosing, E Castoldi, J C Osselaer, R Saxena, A Smith, M Waite, G Standen, T Clench, J Thumpston, H Vetr, M A Vasef, G Willis, H White, R Zadro, P Wright, D Keeling, J Zehnder | 2004 |
1st International Genetic Reference Panel for Prothrombin Mutation (G20210A), Human gDNA (05/130) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Plasma Coagulation Inhibitors Chair:Elaine Gray
Co-chairs:Francesco Bernardi, Frank C Church, Craig J. Jackson, David Lane, Koji Suzuki, Herbert C Whinna | No formal WP.
Key collaborators:
UK NEQAS (Blood Coagulation) | Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI) | N Akar, F Araujo, B Auguston, J Prior, C Ayuso, F Bernardi, C Blackie, D J Bowen, S Brooks, D Perry, P Carroll, J-M Costa, R Das, T Cumming, S Keeney, B Donahue, G Wissel, M S Enayat, J Farrugia, T Fidalgo, M S Figueiredo, O Garach-Jehoshua, B Gilfix, M Hawkins, I Hrachovinova, I Jarvela, A Orpana, S Kadkol, S Kalsheker, M Kambouris, S Kitchen, S Cooper, C Klein, J Marki-Zay, E Koay, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, A Nejad, S Pena, R Sturzeneker, J Rosing, E Castoldi, R Saxena, A Smith, D Snell, G Standen, T Clench, A Valiente, H Vetr, G Willis, H White, V Durston, K Smith, R Zadro, P Wright, D Keeling, R Zadro | 2005 |
5th IS Heparin, porcine mucosal (97/578) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Control of Anticoagulation Chair:Francis E Preston
Co-chairs:Giancarlo Agnelli, Trevor W Barrowcliffe, A.M.H.P. van den Besselaar, Bernard Boneu, Alan R Giles, Leon Poller, Armando Tripodi | Elaine Gray, Trevor Barrowcliffe (Haematology); Dawn Walker (Informatics Laboratory); Barbara Mulloy (Laboratory for Molecular Structure) | G van Dedem, P J Morris, K B Johansen, J F Branellec, D Williamson, T Yin, R Porta, P Shaklee, S Gonella, P Shepherd, E Coyne, F C Arntzen, C Alonso, M E Albertengo, L Best, F Rosenberg, J-M Spieser, T Tanimoto, A Beck, C L van Gorp, J Fareed, S Thomas, R Iampietro, E Sandberg, J Flensburg | 1998 |
2nd IS Low Molecular Weight Heparin (01/608) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Control of Anticoagulation Chair:Mike Greaves
Co-chairs:Henri Bounameaux, Job Harenberg, Clive Kearon,
Michael Laposata, Frits R Rosendaal, Sam Schulman,
Armando Tripodi, A.M.H.P. van den Besselaar | No formal WP.
Key collaborator:
Marie-Emmanuelle Behr-Gross (EDQM) | Elaine Gray (Haematology); Peter Rigsby (Informatics Laboratory) | B Parma, P N Shaklee, G Rautmann, G Cozic, H Nagel, M Schroder, K MacKinnon, M Kovacs, V Dupont, C Alonso, B van Genugten, J Fareed, J Harenberg, E Sandberg, M E Albertengo, L Oliva, M Esnaola, C Loh, J J Descombe, R Domanig, J I Weitz, A C Fylling, Y Gourmelin, F Lackner, J Tapon-Bretaudiere, J Dufaux, J Dayan-Kenigsberg, S Kitchen, F C Arntzen, K Erlandsson-Persson, M L Wiesel, S Thomas, F Nicham, E Holmer | 2003 |
6th IS Unfractionated Heparin (WHO/BS/09.2124) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Control of Anticoagulation Chair:Trevor Baglin
Co-chairs:Walter Ageno, Job Harenberg, Clive Kearon, Aharon Lubetsky, John
Olson, Gualtiero Palareti, Sam Schulman, AMHP van den Besselaar | Elaine Gray, John Hogwood, Peter Rigsby, Barbara Mulloy, Anita Y Szajek, Michael R Ambrose, Fabian Jameison, Walter Hauck, Tina S Morris | Ginés Diaz and Maria Mercedes Lopez, Peter Gärtner, Patrick Shaklee, Jesus Cabañas, Maik Gehrke and Gerrit Oldekamp, Eva Sandberg, François Nicham and Nathalie Barat, Guy Rautmann, C.S. Venkatesan, Dean Smith and Hing Chong, Luis Soares, Ljiljana Kudra and Dženita Softic, Donata Bensi, Pilar Carrasco, Bjørn Fehrmann, Oliver Rädler, Fan Huihong and Li Jing, John Hogwood, Hinrich Nagel, Peter Bruegger, Karin Stoll- Rubin, Susanne Alban, Thomas Freudemann, Cécile Auguste and Céline Houiste, Hester Hasper, Hitendra Mehta and Anisha Akula, Wolfgang Klein, Stephanie Berrier, Roger Meier, Barbara Kerbl, Toshimi Murai and Yukari Nakagawa, Chong Loh and Allison Jones, Sérgio Luiz Dalmora, Michael Ambrose and Jeanne Fringer, | 2009 |
3rd IS Plasmin (97/536) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Fibrinolysis Chair:Nuala A Booth
Co-chairs:Paul J Declerck, Cornelis Kluft,
Osamu Matsuo | Patrick J Gaffney, Tracy A Edgell, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory) | J Jespersen, R Lijnen, E Ersdal, T A Edgell, B Binder, V Sarin | 1998 |
IS Plasminogen activator inhibitor - 1, plasma, human (92/654) | Subcommittee | Working Party | NIBSC Personnel | Participants | WHO Establishment |
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| Fibrinolysis Chair:Cornelis Kluft
Co-chairs:Dudley Strickland, Bernd Binder, Jorgen Gram | Key collaborator:
Paul Declerck (Leuven) | Patrick J Gaffney, Tracy A Edgell(Haematology) | B Binder, J Jespersen, S Rosen, P Declerck, T Edgell, M Ranby, C Kluft, N A Booth | 1995 |
1st IS Platelet Factor 4 (83/505) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Platelets Chair:Barry S Coller
Co-chairs:Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith | Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics Laboratory) | A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub | 1984 |
3rd IS Streptokinase (00/464) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Fibrinolysis Chair:Paul J Declerck
Co-chairs:Nuala A Booth, Carl-Erik H Dempfle, Osamu Matsuo, Michael Nesheim | Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory) | E Sandberg, S Agerholm, J Jespersen, J Sidelmann, E Anglés-Cano, V Bottiger, M Knorst, K S Chief, M Orlando, R Sardelli, I Altieri, E Charton, A E Sterin Prync, C M Buslje, S M Dabsys, T Urano, H Wu, M Xu, M Zhang, H R Lijnen, C Whitton, C Longstaff, C L Reed, A V Sriram, D Vijayarangam, S Pullamsetti, Y Martinez | 2001 |
2nd IS Streptodornase (WHO/BS/09.2112) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Fibrinolysis Chair:Colin Longstaff
Co-chairs:Carl-Erik Dempfle, Ann Gils, Dirk Hendriks, Osamu Matsuo, Michael Nesheim, Tetsumei Urano | Colin Longstaff , Peter Rigsby | Reinhard Paul, Mabel Izquierdo Lopez, Jyoti Patel, Hee-Sung Kim, Seungno Yang, V.K.Srinivas | 2009 |
3rd IS Tissue Plasminogen Activator, human, recombinant (98/714) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
|---|
| Fibrinolysis Chair:Nuala A Booth
Co-chairs:Paul J Declerck, Carl-Erik H Dempfle, Osamu Matsuo | Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory) | A Takada, B R Binder, A Meunier, S Bassarab, A Farrugia, A Mackerras, J Jespersen, N Sakuragawa, N A Booth, T Sullivan, D C Rijken, C Longstaff, S Rosen, C Whitton, E Anglés-Cano | 2000 |
IS High Molecular Weight Urokinase (87/594) | Subcommittee | NIBSC Personnel | Participants | WHO Establishment |
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| Fibrinolysis Chair:David J Loskutoff
Co-chairs:R.S. Schleef, M Egbert Kruithof, H. Pannekoek, Patrick Gaffney, David C Stump | Patrick J Gaffney (Haematology);Alan Heath (Informatics Laboratory) | P Sackett, E K O Kruithof, H R Lijnen, M Samama, L Mahlen, D Beebe, A Metz, J B Pring, W A Gunzler, M Nobuhara, R Kussat | 1989 |
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