International Society on Thrombosis and Haemostasis

SSC- WHO Standards

Contact ISTH

The SSC is grateful for the generous participation of many members in the generation of good standards data, which underpins so much of the work of the SSC and ISTH. We have created this record for standards adopted by WHO/ECBS in recent years as a way of acknowledging the input of time, expertise and reagents. We may be missing information for some older standards. Please advise Cary Clark (headquarters@isth.org) of any additional information.

Plasma Standards • Concentrate Standards • Fibrinolytics and Anticoagulants

Plasma Standards

2nd International Standard for Antithrombin, plasma (93/768)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Sadaaki Iwanaga Co-chairs: R.M. Bertina, Born Dahlbäck, Takehiko Koide, David Lane	Trevor Barrowcliffe, Jane Watton (Haematology); Alan Heath (Informatics Laboratory)	K Benford, E Briet, A-M Fischer, D J Warnuek, S Fedy, J Conard, J Fareed, M Johnston, J Maynard, P Cooper, F E Preston, H P Beeser, H Ridgeway, J Lloyd, E Duncan, J Watton, T W Barrowcliffe, A Tripodi, J Brandt, C Wagner, A-S Carlstrom, U Abildgaard, J Arnout	1994

3rd International Standard for Antithrombin, plasma

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Herbert C Whinna Co-chairs: Francesco Bernardi, Elaine Gray, Tilman Hackeng, Steven Kitchen, Richard Marlar, P Meijer, Laurent Mosnier	John Hogwood, Michelle Hamill, Peter Rigsby, Elaine Gray	D Adcock, L Desjardin, J Amiral, P Baker, N Barat, F Nicham, M Bono, C Caron, G Hickman, J Conkie, P Cooper, E Biguzzi, D Asti, D Foulon, L Germain, C Ludlam, J Hogwood, H Hoogendoorn, A Jones, T Kerim, B Kerbl, A Lichte, R Luddington, S Nair, A Srivastava, J Rentenaar, A Riddell, J Jespersen, J Sidelmann, K Trumbull, K Villadsen, A-M Hvas, Renata Zadro	2010

1st International Standard for C-1 Inhibitor, Plasma (08/262)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Chair: Thomas Renne Co-chairs: David Gailani, Keith McCrae	Craig Thelwell, Peter Rigsby, Colin Longstaff	S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz	2010

Subcommittee

NIBSC Personnel

Participants

WHO Establishment

Chair: Thomas Renne
Co-chairs: David Gailani, Keith McCrae

Craig Thelwell, Peter Rigsby, Colin Longstaff

S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz

2010

3rd International Standard Factors II, VII, IX, X, plasma (99/826)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair: Donna DiMichele Co-Chairs:Jørgen Ingerslev, Christine Lee, Koen. Mertens, Claude G Negrier, Johannes Oldenburg,Dorothea Scandella, Akira Yoshioka	Elaine Gray, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory)	R Bader, J Gillissen, P Braun, C Lessard, M Seidler, K Denson, D Howarth, F Ofosu, F van der Meer, R Parkinson, S Lees, S Kitchen, B Sampson, J Lloyd, J Ingerslev, H Ridgeway, L Lottin, M Robers, H Lehmann, L Weller, R Iampetrio, S Thomas	2001

4th International Standard Factors II, VII, IX, X, plasma (09/172)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair: Alok Srivastava Co-Chairs: Jan Astermark, Kathelijn Fischer, Charles Hay, Claude Negrier, Johannes Oldenburg, Flora Peyvandi, Edward Tuddenham, Leonard Valentino	Elaine Gray, Helen Barson, Jason Hockley, Peter Rigsby	R Zadro, J.M.Rentenaar, K Sukhu, J Jespersen, J Sidelmann, S Nair, M Timme, R Luddington, M Boylan, R Bader, C Caron, K Villadsen, A-M Hvas, C Ludlam, L Germain, J Amiral, D Adcock, L Desjardin, A Riddell, M Bono, K Trumbull, W Olend, B Kerbl, D Foulon, H Hoogendoorn, J McGrath, H Barson, M Beeharry, N Barat, F Nicham, J Conkie, G Hickman, S Rosen, A Bowyer, L Saminaden, J Gillissen, K Bradley, C Loh, A Jones, T kerim, N Lucchesi, D Gambelli	2010

1st International Standard for Blood Coagulation Factor V in Plasma, Human (03/116)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and Factor IX Chair: Koen Mertens Co-Chairs: Joan Cox Gill, Christine Lee, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg	Anthony R. Hubbard (Haematology); Suzanne Johnes (Informatics Laboratory)	A Hunfeld, J M Rentenaar, R Bader, S Kitchen, A Bowyer, K Trumbull, M Shima, C Lee, A Riddell, C Caron, H Metzner, F Nicham, J Weinberger, B Kerbl, A Hubbard, L J Weller, S Berrier, R Veinotte, S Duff, S Rosen, C Loh, P Giangrande, K Sukhu, J V Lloyd, E Duncan, A Tosetto, A Cappelletti, JCJ Eikenboom, D Harz	2005

5th International Standard for Blood Coagulation Factor VIII and Von Willebrand Factor in Plasma, Human (02/150)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and Factor IX Chair: Donna DiMichele Co-Chairs: Christine Lee, Koen Mertens, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg Von Willebrand Factor Chair: Robert R Montgomery Co-Chairs: Giancarlo Castaman, Jeroen C.J. Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, David Lillicrap, Claudine Mazurier	Anthony R Hubbard (Haematology), Alan B Heath (Informatics Laboratory)	A Yoshioka, K Sukhu, P Giangrande, R Bader, J V Lloyd, J Endres, C Eby, R Kotitschke, S Joyon, H Metzner, C andreini, S Rosen, S Duff, S Cinotti, C Watson, M Griffiths, M G Riera, M Ledford, F Rodeghiero A Tosetto, J M Lusher, C Wiseman, M Wolf, P Turecek, E Favaloro, A Hunfeld, K Trumbull, C Mazurier, B Samor, M Knorst, S Bevan, L Weller, J Patzke, C A Ludlam, C Michalski, D A Triplett, S Kitchen, B Sampson, C A Lee, A Riddell, M Grimaux, J Ingerslev, C Caron, C M Eckmann	2003

Subcommittee

NIBSC Personnel

Participants

WHO Establishment

Factor VIII and Factor IX

Chair: Donna DiMichele
Co-Chairs: Christine Lee, Koen Mertens, Johannes Oldenburg, Jean-Marie Saint-Remy, Alok Srivastava, HM van den Berg

Von Willebrand Factor

Chair: Robert R Montgomery
Co-Chairs: Giancarlo Castaman, Jeroen C.J. Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, David Lillicrap, Claudine Mazurier

Anthony R Hubbard (Haematology), Alan B Heath (Informatics Laboratory)

A Yoshioka, K Sukhu, P Giangrande, R Bader, J V Lloyd, J Endres, C Eby, R Kotitschke, S Joyon, H Metzner, C andreini, S Rosen, S Duff, S Cinotti, C Watson, M Griffiths, M G Riera, M Ledford, F Rodeghiero A Tosetto, J M Lusher, C Wiseman, M Wolf, P Turecek, E Favaloro, A Hunfeld, K Trumbull, C Mazurier, B Samor, M Knorst, S Bevan, L Weller, J Patzke, C A Ludlam, C Michalski, D A Triplett, S Kitchen, B Sampson, C A Lee, A Riddell, M Grimaux, J Ingerslev, C Caron, C M Eckmann

2003

1st International Standard for Blood Coagulation Factor XI in Plasma, Human (04/102) and Calibration of Blood Coagulation Factor XI in SSC Secondary Plasma Standard Lot#3

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Kallikrein-Kinin System Chair: Keith R McCrai Co-Chairs: Raul A DeLa Cadena, David Gailani Michael J Gallimore, Hidehiko Saito, Alvin H Schmaier Working Group on Plasma Coagulation Standards Chair: Jane Lenahan	Elaine Gray, Stephen Thomas (Haematology); Peter Rigsby (Informatics Laboratory)	R Bader, A Bianchi Bonomi, A Bellisario, A Starace, S Antimo, A Birchall, A Abrahams, P Bolton-Maggs, D Shanks, S Duff, M Boylan, E Duncan, C Casey, D Elminger, T Fanella, D Gailani, G Baxter, J Gillissen, K Bradley, P Harper, L Glogoski, A Hunfeld, S Rosenkranz, L Ivey, W Jones, S Harris, B Kerbl, S Kitchen, A Bowyer, D Lawson, P Braun, L Lim, M Taylor, I Mackie, A Lawrie, K Mertens, C Eckmann, G Rautmann, U Selgsohn, A Zivelin, I Tamarin, K Sukhu, S Thomas, K Trumbull, B Phillips, J Weinberger, D Krause, L Weller	Oct. 2005

Subcommittee

NIBSC Personnel

Participants

WHO Establishment

Plasma Kallikrein-Kinin System

Chair: Keith R McCrai
Co-Chairs: Raul A DeLa Cadena, David Gailani Michael J Gallimore, Hidehiko Saito, Alvin H Schmaier

Working Group on Plasma Coagulation Standards

Chair: Jane Lenahan

Elaine Gray, Stephen Thomas (Haematology); Peter Rigsby (Informatics Laboratory)

R Bader, A Bianchi Bonomi, A Bellisario, A Starace, S Antimo, A Birchall, A Abrahams, P Bolton-Maggs, D Shanks, S Duff, M Boylan, E Duncan, C Casey, D Elminger, T Fanella, D Gailani, G Baxter, J Gillissen, K Bradley, P Harper, L Glogoski, A Hunfeld, S Rosenkranz, L Ivey, W Jones, S Harris, B Kerbl, S Kitchen, A Bowyer, D Lawson, P Braun, L Lim, M Taylor, I Mackie, A Lawrie, K Mertens, C Eckmann, G Rautmann, U Selgsohn, A Zivelin, I Tamarin, K Sukhu, S Thomas, K Trumbull, B Phillips, J Weinberger, D Krause, L Weller

Oct. 2005

1st International Standard for Factor XIII, Plasma (02/206)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Factor XIII Chairman: Robert Ariens Co-Chairs: Paul Bishop, Akitada Ichinose	Factor XIII Standardization WP (Akitada Ichinose, Chair, Trevor Barrowcliffe, Laszlo Muszbek, Rainer Seitz, Robert. Ariens)	Sanj Raut, Elizabeth Merton, Trevor Barrowcliffe (Haematology);Peter Rigsby, Daniella Belgrave (Informatics Laboratory)	M. Arai, R. Ariens, M. Boothby, N. Booth, N. Moore, A. Birchall, G. Castaman, A Tosetto, C. Caron, M. Dreyfus, M. Hanss, A. Hunfeld, H.I. Hassouna, A. Inbal, A. Ichinose, S.M. Kang, H.P. Kohler, V. Schroeder, K. Christian, S. Kingsland, M.Knorst, D.S. Lee, J.C.M. Meijers, H. Metzner, L. Muszbek, B. Polack, S Raut, E. Merton, K. Sukhu, M. Wilmer, K. Rudin, M. Wilkens	2004

2nd International Standard for Fibrinogen, plasma (98/612)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinogen Chair: Michael W Mosesson Co-chairs: Frank Brosstad, Michio Matsuda, Willem Nieuwenhuizen, Ron McIntosh	Patrick J Gaffney, Colin M Whitton, Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory)	E Bovill, H Lang, J-D Schreiber, D Howarth, W Nieuwenhuizen, S Kitchen, I J Mackie, A S Lawrie, J Conkie, R Bader, J A Ruiz, M Boldt, J L Martinoli, C Whitton	1999

1st International Standard for Protein C, Plasma, Human (86/622)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Protein C and S Chair: RM Bertina Co-Chairs: RR Montgomery, JH Griffin, JP Miletich, AR Hubbard, I Pabinger, AW Broekmans	Anthony R Hubbard, Duncan P Thomas (Haematology)	U Becker, RM Bertina, B Chambrette, A Dessauer, D Green, JH Griffin, AR Hubbard, H Lang, MJ Larrieu, PM Mannucci, RA Marlar, K Mertens, S Rosen, N Sala, I Scharrer, H Vinazzer, S Wasi	1987

2nd International Standard for Protein C, plasma (02/342)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Elaine Gray Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna	Elaine Gray, William Pickering (Haemostasis); Peter Rigsby (Informatics Laboratory);	J Amiral, E Biguzzi, D Asti, P Baker, P Braun, S Berrier, C Bisson, P Gärtner, M Johnston, J McGrath, B Kerbl, S Kitchen, P Cooper, C Loh, M Harvey, C Michalski, S Morriso, I Pabinger-Fasching, W Pickering, M Ramondetta, L Leo, J Rentenaar, C-H Toh, A Smith, K Trumbull, B Phillips, B Woodhams, R Zadro	2006

1st International Standard for Protein S, Plasma, Human (93/590)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Chair: Takehiko Koide Co-Chairs: RM Bertina, Bjorn Dahlback, Sadaaki Iwanaga, David Lane	Anthony R Hubbard (Haematology)	AM Burn, F Franchi, A Tosetto, RM Bertina, J Amiral, I Walker, J Conkie, J J Michiels, HHDM van Vliet, I Pabinger, B Woodhams, M Burgess-Wilson, H Lang, B Dahlback, R A Marlar, D Meyer, F E Preston, P Cooper, A R Hubbard, A Lawrie	1995

2nd International Standard for Protein S, plasma (03/228)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Elaine Gray Co-chairs: Francesco Bernardi, Koji Suzuki, Herbert C Whinna	Anthony R Hubbard, Lynne Weller (Haemostasis); Alan B Heath (Informatics Laboratory)	E Biguzzi, D Asti, P Baker, M Stegnar, A Smith, M Johnston, B Kerbl, M Smith, A R Hubbard, L J Weller, J C J Eikenboom, R Marlar, I Pabinger, R Zadro, K Mertens, J Rentenaar, J Patzke, D D Castellone, S Berrier, M-O Couche, S Lees, P Cooper, S Kitchen, J Conkie, C Legnani, G Palareti	2006

1st IS for Tissue Plasminogen Activator (tPA) Antigen, Plasma (94/730)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Colin Longstaff Co-Chairs: Carl-Erik H. Dempfle, Ann Gils, D Hendriks, Osamu Matsuo, Michael E. Nesheim	Colin Whitton, Peter Rigsby, Colin Longstaff	Yves Gourmelin, Stéphanie Berrier, Barbara Kerbl, Jean Amiral, Ann Rumley/Gordon Lowe, Norma Moore/Nuala Booth, Tetsumei Urano, Pamela Dawson, Colin Whitton, Annika Sköld, Renate Beckmann, Paul Declerck, J.C.M. Meijers	2007

4th International Standard for Thromboplastin, Rabbit, Plain

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Control of Anticoagulation Chair: Sam Schulman Co-Chairs: Mike Greaves, Job Harenberg, Clive Kearon, Michael Laposata, John Olson, Gualtiero Palareti, F.R. Rosendaal, AMHP van den Besselaar		P Angchaisuksiri, K Aryurachai, M Borrell, V Chantarangkul, A Tripodi, K Denson, T Gago, P Herbel, A Jünschke, W Plesch, M Johnston, S Kitchen, C Legnani, T Lindahl, R Manning, M Martinuzzo, D Mezzano, N Opartkiattikul, K Overgaard, J Jespersen, V Pengo, M Persson, A Hillarp, R Redaelli, F Baudo, P Rojnuckarin, B Akkawat, E Witteveen, AMHP van den Besselaar, H Wada	2005

6th IS Factor VIII/von Willebrand factor Plasma (WHO/BS/09.2116)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX< Chair: Alok Srivastava Co-Chairs: Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham von Willebrand Factor Chair: David Lillicrap Co-Chairs: Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Jereon Eikenboom, Emmanuel Favaloro, Anne Goodeve, Bernhard Lammle, Reinhard Schneppenheim	Anthony R. Hubbard, Michelle Hamill, Malinee Beeharry, Sally Bevan, Alan B. Heath	M Shima, S Duff, M Boylan, K Sukhu, P Giangrande, S Cinotti, R Bader, C Watson, E Duncan, B Kerbl, K Friedman, J Endres, G Riera, C Eby, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, B Woodhams, M Wolf, A Lichte, J Patzke, M Timme, P Turecek, H Gritsch, C Andreini, E J Favaloro, S Rosén, A Hunfeld, J Fötisch, A Schroda, R Nawroth, D Elmlinger, K Trumbull, M Blum, J Amiral, B Samor, S Bevan, M Beeharry, M Bono, J C J Eikenboom, C A Ludlam, L Germain, S Kitchen, K Goodfellow, K Pock, A Federici, M T Canciani, A Riddell, J Conkie, G Hickman, S Berrier, C Caron, M Telesca, C M Eckmann, G Longin, P Gärtner, G Rautmann, C Raphalen, D Krause, A Blande	2009

Subcommittee

NIBSC Personnel

Participants

WHO Establishment

Factor VIII and IX<

Chair: Alok Srivastava
Co-Chairs: Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham

von Willebrand Factor

Chair: David Lillicrap
Co-Chairs: Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Jereon Eikenboom, Emmanuel Favaloro, Anne Goodeve, Bernhard Lammle, Reinhard Schneppenheim

Anthony R. Hubbard, Michelle Hamill, Malinee Beeharry, Sally Bevan, Alan B. Heath

M Shima, S Duff, M Boylan, K Sukhu, P Giangrande, S Cinotti, R Bader, C Watson, E Duncan, B Kerbl, K Friedman, J Endres, G Riera, C Eby, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, B Woodhams, M Wolf, A Lichte, J Patzke, M Timme, P Turecek, H Gritsch, C Andreini, E J Favaloro, S Rosén, A Hunfeld, J Fötisch, A Schroda, R Nawroth, D Elmlinger, K Trumbull, M Blum, J Amiral, B Samor, S Bevan, M Beeharry, M Bono, J C J Eikenboom, C A Ludlam, L Germain, S Kitchen, K Goodfellow, K Pock, A Federici, M T Canciani, A Riddell, J Conkie, G Hickman, S Berrier, C Caron, M Telesca, C M Eckmann, G Longin, P Gärtner, G Rautmann, C Raphalen, D Krause, A Blande

2009

Concentrate Standards

2nd IS Antithrombin, concentrate (96/520)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Takehiko Koide Co-chairs: Martine. Aiach, R.M. Bertina, Frank C Church, Born Dahlbäck), Hisao Kato, David Lane	Elaine Gray (Haematology); Dawn Walker, Alan Heath (Informatics Laboratory)	L Engman, H Lang, J-D Schreiber, C Mazurier, G E C Sims, G H Kurt, J Dodt, H Eran, H G Müller, S Mizusawa, K Vora, C Yee, N-E Andersson, O Santaeularia, H Tanaka, C Alonso, A Chiodo, B Whittaker, R J Mattaliano, S Thomas, S Margetts, A Wozniak	1997

3rd IS for Antithrombin, concentrate (06/166)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Elaine Gray Co-chairs: Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna	Elaine Gray, John Hogwood, Matthew Brierley, Peter Rigsby	Andrea Lichte, Catherine Michalski, Celia Monnier, David Gambelli, Denise Foulon, Eva Sandberg, Guy Rautmann, Holger Blessing, J M Rentenaar, John Hogwood, Jerry Grandoni, Koen van der Drift, Lu Liu Mandy Blande, Manuela Leitner, Peter Gärtner, Raffaella Sardelli, Rolf Hovik, Silva Bergqvist, Steve Kitchen, Peter Cooper, Susanne Breitner-Ruddock	2007

1st International Standard for C-1 Inhibitor, Concentrate (08/256)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Chair: Thomas Renne Co-chairs: David Gailani, Keith McCrae	Craig Thelwell, Peter Rigsby, Colin Longstaff	S Breitner-Ruddock, N Zander, C Michalski, S Linstead, H Blessing, B Kerbl, D Wouters, E Nieuwenhuys, K Abbink-Wiersum, P Gartner, L Agnes Varga, R Zadro, M Cicardi, E Langer, E Karnaukhova, M López-Trascasa, P Nozal, C Drouet, S Regenass, E Waage Nielson, E Marszal, M Wirz, F Luciani, C Thelwell, P Whitfield, W Egner, K Dengler, K Masselou, T Plant, W Korte, P Roux-Lombard, E. Aygoeren-Pürsün, W. Kreuz	2010

Subcommittee

NIBSC Personnel

Participants

WHO Establishment

Chair: Thomas Renne
Co-chairs: David Gailani, Keith McCrae

Craig Thelwell, Peter Rigsby, Colin Longstaff

2010

3rd IS Factors II, X, concentrate (98/590)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair:Jørgen Ingerslev Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier,Rainer Schwaab, Akira Yoshioka	Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory)	K Mertens, R Parkinson, A Chiodo, J Brandt, A Gaillandre, L Musmanno, H G Müller, R Cooper, G E C Sims, S Lei, L Engman, R Kotitschke, U Kukral, N H Mateu, J Dodt, R Iampietro	1999

1st IS Factor VII, concentrate (97/592)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair:Jørgen Ingerslev Co-chairs:Donna DiMichele, Koen Mertens, Ian R Peake, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka	Anthony R Hubbard, Trevor W Barrowcliffe (Haematology); Peter Rigsby (Informatics Laboratory)	F E Preston, S Kitchen, N-E Andersson, D Howarth, A Gaillandre, A R Hubbard, P M Mannucci, R Bader, G E C Sims, B Lambrecht, K Mertens, R Parkinson, V Hahn, R Kotitschke, H Lang, J-D Schreiber, J Römisch, S C Cheung, C Michalski	1998

1st IS Factor VIIa, concentrate (89/688)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Predictive Variables Chair: Gordon Lowe Co-chairs: J Andrew Davies, Anders Hamsten, Mae Hultin, Kenneth K Wu	Anthony R Hubbard (Haematology)	M J Larrieu, Y Laurian, G E C Sims, A Gaillandre, A R Hubbard, Y Stirling, J K Jacobsen, F Nielsen, A Oates, S Kitchen, C Michalski, H-G Muller, S Lees, H Lang, S Rosen, P M Mannucci, E Niday	1993

7th IS Factor VIII, concentrate (99/678)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair: Donna DiMichele Co-chairs: Christine Lee, Koen Mertens, Johannes Oldenburg, HM van den Berg, Alok Srivastava, Jean-Marie Saint-Remy	Nancy Kirschbaum, Laura Wood, P Lachenbruch, Mark Weinstein (FDA/CBER); Karl-Heinz Buccheit, Jean-Marc Spieser, Arnold Daas (EDQM)	Sanj Raut, Sally Bevan, Anthony R Hubbard, Trevor Barrowcliffe (Haematology); Dawn Sands (Informatics Laboratory)	ME Albertengo, LM Olivia, B Cuthbertson, C Alonso, A Gaillandre, C. Michalski, D Baker, M Alai, N Hosta, D Baker, G Jacoby, AR Hubbard, D Baker, R Kwok, Y Katsubayashi, F Brosstad, R Kleszynski, G Carlin, R Kotitschke, U Kukral, T Najdovski, D Liu, O Shen, Y Ren, U Oswaldsson, C Loh, R Parkinson, K Mertens, G Rautmann, L Mouillot, L Regan, N Mondelo, E Piccinni, M Saenger, L Musmanno, E Sandberg, R. Sardelli, I Altieri, M Orlando, M Weinstein, L Wood, J-D Schreiber, WL Wilson, GEC Sims, F Yeganeh, A Stierle, M Taneichi, P Turecek, E Vahtera	2003

8th IS Factor VIII, concentrate (07/350)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair: Alok Srivastava Co-Chairs: Christine A. Lee, Claude Negrier, Flora Peyvandi, Jean-Marie Saint-Remy, Charles Hay, Johannes Oldenburg, Edward Tuddenham	Sanj Raut, Sarah Daniels, Alan Heath	C Alonso, A Auer, A Banfi, S Hafner, N Kerestes, A Blande, H Blessing, R Paul, C-P Lin, D-Y Wang, Y-C Yang, B-H Chung, M-C Ho, H Chong, D D Huang, R Belcourt, D Elmlinger, M Nuss, D Gambelli, E Cini, P Gärtner, E Helgeson, N Khabbaz, T Allyn, N Hosta, A Hunfeld, R Näther, R Nawrot, L Inder, M Jankowski, S Weston, K Kamimura, M Kjalke, A Danielsen, L Odborg, M Leerabhandh, M Leitner, C Loh, L Liu, C Michalski, L Mouillot, V Lievre, L M Oliva, C LV Maria, M A Nunez, P Aprea, K Pock, M Stadler, J K Rasmussen, F Silva, S Raut, S Daniels, S Bevan, G Rautmann, C Raphalen, S Rosén, P Rosén, E Sandberg, R Sardelli, A da Silva, L Soares, C Figueiredo, L Ventura, M Taneichi, P Turecek, H Gritsch, Y Watanabe, J Weinberger, D Krause, M Wermeille, J-P Chessa, L Wong, B Badiei, M Alai, Y Wang, L Wood, T Lee	2009

3rd IS Factor IX, concentrate (96/854)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair: Ian Peake Co-chairs: Ernest Briët, Jørgen Ingerslev, Carol Kasper, Christopher Prowse, Yvette Sultan	No formal WP. Key collaborators: Mark Weinstein, Thomas J Lynch (CBER)	Trevor Barrowcliffe (Haematology); Joanna Macnab (Informatics Laboratory)	B Cuthbertson, R Kleszynski, A Chiodo, A Farrugia, A Beck, J Brandt, H-G Müller, G E C Sims, R Kotitschke, K Mertens, A Gaillandre, C Mazurier, C Alonso, F Balstrup, E Vahtera, L Mouillot, H Lang, O Santaeularia, Y Miura, J Torres, R Parkinson, M Weinstein, R Schütz, G Tin, U Oswaldsson, J F Wright, A R Hubbard, T Murozuka, P Jongen, E Kung, E Sandberg, W Skare, W Wilson, H Windemann, T Montag-Lessing, G H Kurt	1996

1st IS Factor IXa, concentrate (97/562)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Factor VIII and IX Chair:Jørgen Ingerslev Co-chairs:Donna DiMichele, Koen Mertens, Christopher Prowse, Claude Negrier, Rainer Schwaab, Akira Yoshioka	Elaine Gray (Haematology); Dawn Sands (Informatics Laboratory)	H König, GEC Sims, B Letwin, O Drummond, K Mertens, C Michalski, L Engman, LJY Ho, R Iampietro, S Thomas	1999

1st IS Fibrinogen, concentrate (98/614)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinogen Chair: Susan T Lord Co-chairs: Michio Matsuda, Ron McIntosh, Michael W Mosesson, Willem Nieuwenhuizen	Trevor Barrowcliffe, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)	S Cheung, L Wood, M MacPhee, J T Lathrop, L Jacobs, U Kukral, H Metzner, S Herring, J Morris, J-D Schreiber, B Spitzer-Sonnleitner, P Feldman, S Kingsland, R Talbot, C Backhouse, N Goss, K Almbanis, F Hawkins, D Josic, W Gehringer, P Bishop, K B Lewis, C Fukaya, L Bar, L Lukovenkou, E Feller, R Robson, R Cooper, H Duerr, J P Davis, H Kaetsu, K Odo, C M Whitton	2000

1st IS Protein C, concentrate (04/252)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Elaine Gray Co-chairs: Francesco Bernardi, Steven Kitchen, Richard Marlar, Piet Meijer, Herb Whinna	Elaine Gray, William Pickering, Peter Rigsby	Jean Amiral, Eugenia Biguzzi, Daniela Asti, Peter Baker, Paul Braun, S Berrier, C Bisson, Peter Gärtner, Marilyn Johnston, Mrs Joanne McGrath, Barbara Kerbl, Steven Kitchen, Peter Cooper, Chong Loh, Matt Harvey, Catherine Michalski, Sandy Morrison, Ingrid Pabinger-Fasching, William Pickering, Miriam Ramondetta, Luigi Leo, Jeannette Rentenaar, Cheng-Hock Toh, Alan Smith, Kathleen Trumbull, Barbara Phillips, Barry Woodhams, Renata Zadro	2007

2nd IS Thrombin (01/580)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Fibrinogen Chair: Susan T Lord Co-chairs: Jaap Koopman, Ron McIntosh, Nicodemo Weinstock	No formal WP. Key collaborators: Andrew Chang, Tomothy Lee (CBER/FDA)	Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)	R Cooper, M Knorst, R Kotischke, W Hong, E Sandberg, M E Albertengo, L Oliva, C Meuller, J Wang, R Sardelli, I Altieri, C Hardway, H-F Cheng, S M-C Ho, I Bravo, U Oswaldsson, M Saenger, V Gatzigiannis, C K Lee, A Terrab, J Rosser, T Najdovski, P Vanschonbeek, H Kaetsu, C Whitton, Q Shen, U Unkelbach, U Kukral, P Gaertner, J D Schreiber, W Jaklitsch	2003

1st IS von Willebrand Factor, concentrate (00/514)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
von Willebrand Factor Chair: Robert R Montgomery Co-chairs: Jeroen Eikenboom, Augusto B Federici, Anne Goodeve, Peter A Kouides, Claudine Mazurier, Jacob H Rand, Francesco. Rodeghiero	No formal WP. Key collaborators: Andrew C Chang (CBER/FDA, USA), Claudine Mazurier (LFB, France)	Anthony R Hubbard (Haematology); Dawn Sands (Informatics Laboratory)	C Loh, A Farrugia, J Kanellos, R Sardelli, J Weinberger, D Gambelli, G E C Sims, U Kukral, M Stadler, W K Stevens, A Riddell, C Lee, C Michalski, M T Canciani, A B Federici, J-D Schreiber, C Miller, C Mazurier, B Samor, K Friedman, R Montgomery, B Neugebauer, E Favaloro, P Turecek, M G Riera, H-G Müller, A C Chang, A R Hubbard, L J Weller, J Lusher, C Wiseman, G Mohn, F Rodeghiero, A Tosetto	2001

2nd IS von Willebrand Factor, concentrate (09/182)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
von Willebrand Factor Chair: Jeroen Eikenboom Co-chairmen: Thomas Abshire, Imre Bodo, Giancarlo Castaman, Jorge DiPaola, Emmanuel J Favaloro, Anne Goodeve, Bernhard Lämmle, David Lillicrap, Reinhard Schneppenheim	Anthony R Hubbard, Michelle L Hamill, Malinee Beeharry, Sally A Bevan and Alan B Heath	M Shima, K Sukhu, D Keeling, E Duncan, J Endres, K Friedman, S Langlet, S Duff, M Boylan, T Willis, K C Matthews, C Watson, B Hopkins, B Kerbl, M G Riera, F Rodeghiero, A Tosetto, M Chitlur, J M Lusher, P Turecek, H Gritsch, E J Favaloro, A Hunfeld, Ms Schroda, Ms Sächerl, Ms Näther, K Trumbull, W Olend, C Michalski, B Samor, E Lefebvre, M Beeharry, S Bevan, C A Ludlam, L Germain, S Kitchen, A Bowyer, B Sampson, A Riddell, S Berrier, C Bisson, M Weinstein, D Lebel, C Caron, D Lillicrap, A Tuttle, C M Eckmann, J Rentenaar, P Gärtner, D Gambelli, N Lucchesi, J Weinberger, D Krause, S Nair, A Srivastava, J Amiral, M Bono, H C J Eikenboom, C van Rijn, M Stadler, F Peyvandi, M T Canciani, A Blande, H Blessing, P Bayer, C Burgess, P Credland, J Patzke, A Jones, N Hosta, S Gigan, V Lievre, H Chong	2010

Fibrinolytics and Anticoagulants etc.

1st IS Beta thromboglobulin, purified, human (83/501)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Platelets Chair: Barry S Coller Co-chairs: Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith	Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics laboratory)	A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub	1984

1st International Genetic Reference Panel Factor V Leiden, Human gDNA (04/224)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Frank C Church Co-chairs: Francesco Bernardi, Elaine Gray, Craig J. Jackson, David Lane, Koji Suzuki	No formal WP. Key collaborators: UK NEQAS (Blood Coagulation)	Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI)	N Akar, F Araujo, Y Ayob, F Bernardi, C Blackie, D J Bowen, S Bowley, S Brooks, D Perry, P Carr, R Das, T Cumming, S Keeney, L Emiliusen, J Heit, A D Gupta, W Erber, M S Enayat, M S Figueiredo, J Farrugia, A Copplestone, G Gibbs, S V Davies, O Gerach-Jelaushun, S Kalsheker, I Hrachovinova, E Lindhoff-Last, S Kitchen, S Cooper, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, M Morrison, J Rosing, E Castoldi, J C Osselaer, R Saxena, A Smith, M Waite, G Standen, T Clench, J Thumpston, H Vetr, M A Vasef, G Willis, H White, R Zadro, P Wright, D Keeling, J Zehnder	2004

1st International Genetic Reference Panel for Prothrombin Mutation (G20210A), Human gDNA (05/130)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Plasma Coagulation Inhibitors Chair: Elaine Gray Co-chairs: Francesco Bernardi, Frank C Church, Craig J. Jackson, David Lane, Koji Suzuki, Herbert C Whinna	No formal WP. Key collaborators: UK NEQAS (Blood Coagulation)	Elaine Gray, Paul Metcalfe (Haematology); Ross Hawkins (CBI); Paul Matejtschuk (TDI)	N Akar, F Araujo, B Auguston, J Prior, C Ayuso, F Bernardi, C Blackie, D J Bowen, S Brooks, D Perry, P Carroll, J-M Costa, R Das, T Cumming, S Keeney, B Donahue, G Wissel, M S Enayat, J Farrugia, T Fidalgo, M S Figueiredo, O Garach-Jehoshua, B Gilfix, M Hawkins, I Hrachovinova, I Jarvela, A Orpana, S Kadkol, S Kalsheker, M Kambouris, S Kitchen, S Cooper, C Klein, J Marki-Zay, E Koay, C Mannhalter, R Mahfouz, D McDonald, M Margaglione, M Neumaier, A Nejad, S Pena, R Sturzeneker, J Rosing, E Castoldi, R Saxena, A Smith, D Snell, G Standen, T Clench, A Valiente, H Vetr, G Willis, H White, V Durston, K Smith, R Zadro, P Wright, D Keeling, R Zadro	2005

5th IS Heparin, porcine mucosal (97/578)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Control of Anticoagulation Chair: Francis E Preston Co-chairs: Giancarlo Agnelli, Trevor W Barrowcliffe, A.M.H.P. van den Besselaar, Bernard Boneu, Alan R Giles, Leon Poller, Armando Tripodi	Elaine Gray, Trevor Barrowcliffe (Haematology); Dawn Walker (Informatics Laboratory); Barbara Mulloy (Laboratory for Molecular Structure)	G van Dedem, P J Morris, K B Johansen, J F Branellec, D Williamson, T Yin, R Porta, P Shaklee, S Gonella, P Shepherd, E Coyne, F C Arntzen, C Alonso, M E Albertengo, L Best, F Rosenberg, J-M Spieser, T Tanimoto, A Beck, C L van Gorp, J Fareed, S Thomas, R Iampietro, E Sandberg, J Flensburg	1998

2nd IS Low Molecular Weight Heparin (01/608)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Control of Anticoagulation Chair: Mike Greaves Co-chairs: Henri Bounameaux, Job Harenberg, Clive Kearon, Michael Laposata, Frits R Rosendaal, Sam Schulman, Armando Tripodi, A.M.H.P. van den Besselaar	No formal WP. Key collaborator: Marie-Emmanuelle Behr-Gross (EDQM)	Elaine Gray (Haematology); Peter Rigsby (Informatics Laboratory)	B Parma, P N Shaklee, G Rautmann, G Cozic, H Nagel, M Schroder, K MacKinnon, M Kovacs, V Dupont, C Alonso, B van Genugten, J Fareed, J Harenberg, E Sandberg, M E Albertengo, L Oliva, M Esnaola, C Loh, J J Descombe, R Domanig, J I Weitz, A C Fylling, Y Gourmelin, F Lackner, J Tapon-Bretaudiere, J Dufaux, J Dayan-Kenigsberg, S Kitchen, F C Arntzen, K Erlandsson-Persson, M L Wiesel, S Thomas, F Nicham, E Holmer	2003

6th IS Unfractionated Heparin (WHO/BS/09.2124)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Control of Anticoagulation Chair: Trevor Baglin Co-chairs: Walter Ageno, Job Harenberg, Clive Kearon, Aharon Lubetsky, John Olson, Gualtiero Palareti, Sam Schulman, AMHP van den Besselaar	Elaine Gray, John Hogwood, Peter Rigsby, Barbara Mulloy, Anita Y Szajek, Michael R Ambrose, Fabian Jameison, Walter Hauck, Tina S Morris	Ginés Diaz and Maria Mercedes Lopez, Peter Gärtner, Patrick Shaklee, Jesus Cabañas, Maik Gehrke and Gerrit Oldekamp, Eva Sandberg, François Nicham and Nathalie Barat, Guy Rautmann, C.S. Venkatesan, Dean Smith and Hing Chong, Luis Soares, Ljiljana Kudra and Dženita Softic, Donata Bensi, Pilar Carrasco, Bjørn Fehrmann, Oliver Rädler, Fan Huihong and Li Jing, John Hogwood, Hinrich Nagel, Peter Bruegger, Karin Stoll- Rubin, Susanne Alban, Thomas Freudemann, Cécile Auguste and Céline Houiste, Hester Hasper, Hitendra Mehta and Anisha Akula, Wolfgang Klein, Stephanie Berrier, Roger Meier, Barbara Kerbl, Toshimi Murai and Yukari Nakagawa, Chong Loh and Allison Jones, Sérgio Luiz Dalmora, Michael Ambrose and Jeanne Fringer,	2009

3rd IS Plasmin (97/536)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Nuala A Booth Co-chairs: Paul J Declerck, Cornelis Kluft, Osamu Matsuo	Patrick J Gaffney, Tracy A Edgell, Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)	J Jespersen, R Lijnen, E Ersdal, T A Edgell, B Binder, V Sarin	1998

IS Plasminogen activator inhibitor - 1, plasma, human (92/654)

Subcommittee	Working Party	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Cornelis Kluft Co-chairs: Dudley Strickland, Bernd Binder, Jorgen Gram	Key collaborator: Paul Declerck (Leuven)	Patrick J Gaffney, Tracy A Edgell (Haematology)	B Binder, J Jespersen, S Rosen, P Declerck, T Edgell, M Ranby, C Kluft, N A Booth	1995

1st IS Platelet Factor 4 (83/505)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Platelets Chair: Barry S Coller Co-chairs: Bruce C Furie, Adrian R L Gear, Karen L Kaplan, Rodger P McEver, Alan T Nurden, J Bryan Smith	Phillip Kerry, Duncan Thomas (Haematology); Anthony Curtis (Informatics Laboratory)	A de Boer, J P Caen, C N Chesterman, J Dawes, K L Kaplan, P J Kerry, P G Malan, S Niewiarowski, M Weintraub	1984

3rd IS Streptokinase (00/464)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Paul J Declerck Co-chairs: Nuala A Booth, Carl-Erik H Dempfle, Osamu Matsuo, Michael Nesheim	Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)	E Sandberg, S Agerholm, J Jespersen, J Sidelmann, E Anglés-Cano, V Bottiger, M Knorst, K S Chief, M Orlando, R Sardelli, I Altieri, E Charton, A E Sterin Prync, C M Buslje, S M Dabsys, T Urano, H Wu, M Xu, M Zhang, H R Lijnen, C Whitton, C Longstaff, C L Reed, A V Sriram, D Vijayarangam, S Pullamsetti, Y Martinez	2001

2nd IS Streptodornase (WHO/BS/09.2112)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Colin Longstaff Co-chairs: Carl-Erik Dempfle, Ann Gils, Dirk Hendriks, Osamu Matsuo, Michael Nesheim, Tetsumei Urano	Colin Longstaff , Peter Rigsby	Reinhard Paul, Mabel Izquierdo Lopez, Jyoti Patel, Hee-Sung Kim, Seungno Yang, V.K.Srinivas	2009

3rd IS Tissue Plasminogen Activator, human, recombinant (98/714)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: Nuala A Booth Co-chairs: Paul J Declerck, Carl-Erik H Dempfle, Osamu Matsuo	Colin Longstaff , Colin Whitton (Haematology); Dawn Sands (Informatics Laboratory)	A Takada, B R Binder, A Meunier, S Bassarab, A Farrugia, A Mackerras, J Jespersen, N Sakuragawa, N A Booth, T Sullivan, D C Rijken, C Longstaff, S Rosen, C Whitton, E Anglés-Cano	2000

IS High Molecular Weight Urokinase (87/594)

Subcommittee	NIBSC Personnel	Participants	WHO Establishment
Fibrinolysis Chair: David J Loskutoff Co-chairs: R.S. Schleef, M Egbert Kruithof, H. Pannekoek, Patrick Gaffney, David C Stump	Patrick J Gaffney (Haematology); Alan Heath (Informatics Laboratory)	P Sackett, E K O Kruithof, H R Lijnen, M Samama, L Mahlen, D Beebe, A Metz, J B Pring, W A Gunzler, M Nobuhara, R Kussat	1989