Stroke is the second leading cause of death worldwide with limited treatment options. Rapid restoration of blood flow by thrombolysis or thrombectomy is the mainstay of acute stroke treatment, but recanalisation of cerebral vessels may trigger ischemia/reperfusion injury and thus infarct growth “despite reperfusion.” Bernhard Nieswandt will discuss increasing experimental evidence suggesting that this cerebral I/R injury is a complex pathology since it involves concerted detrimental actions of platelets and T-cells, referred to as “thrombo-inflammation.” Martine Jandrot-Perrus will review the characteristics of platelet Glycoprotein VI (GPVI) and why GPVI is currently considered to meet the challenge of developing a safe and effective antiplatelet drug.

Mechanisms of Ischemic Stroke

ISTH Core Curriculum 12.1-12.2 – Arterial thrombosis

February 24, 2016 13:00-14:00 UTC

Speakers:

Bernhard Nieswandt "The role of platelets in stroke"

Martine Jandrot-Perrus "GPVI as a novel target in thrombosis"

Moderator: Steve Watson

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