Vascular Biology

This Subcommittee is focused on basic and translational research related to vascular biology and related (athero)-thrombotic disorders, through the development of biomarkers that require standardization. These topics are: 1] Neurophil-extracellular traps ; 2] Circulating endothelial progenitor and cells (EPC and CEC ); and 3] Extracellular vesicles. This SSC incorporates hematologists, laboratory scientists, clinicians and industry scientists, and is a forum of exchanges at the interface with other sub-committees (including Malignancy and Hemostasis, and DIC) and with other Societies (such as ISAC)

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Mandate

• To delineate consensual definition and nomenclature
• To propose new methods of measurement
• To adresse issues of practical importance related to pre-analytic variables
• To establish standardized methodologies
• To develop laboratory calibrants and standards
• To organize collaborative studies to validate these objectives and to delineate the clinical relevance of these biomarkers
• To identify areas of controversy or technological need and discuss methodologic approaches to address questions raised.
• To generate, publish and distribute reports, recommendations and other documents concerning the above.

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Projects

• Standardization of extracellular vesicle measurements by quantifying the quality of scatter flow cytometry
• Collaborative SSC project on standardization of MP counting using calibrated bead standards and high sensitivity-Flow Cytometric platforms
• Collaborative SSC project on development and distribution of traceable reference materials

Official Communication

• Minutes
• Bibliography
• Publication Guidelines