K. Tatsumi, S. Antoniak, D. M. Monroe III, A A. Khorana, N. Mackman and the Subcommittee on Hemostasis and Malignancy
Microparticles (MPs) are small membrane vesicles that are released by activated cells, such as monocytes, cells undergoing apoptosis and tumor cells . Full-length tissue factor (flTF) is a transmembrane receptor for FVII/VIIa and is essentially undetectable in the blood of healthy individuals. However, intravascular levels of flTF are increased in a variety of diseases, including cancer and endotoxemia . The majority of active flTF in plasma in these disease states is present on MPs.