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|Advanced Training Course Oxford|
You're invited to the ISTH Advanced Training Course in Oxford, England, September 6-9, 2016. The meeting will provide three full days of intense examination including education sessions, case sessions and meet the expert sessions devoted to discussion and close interaction with leading experts.
Severe platelet disorders such as Glanzmann’s thrombasthenia, Bernhard Soulier syndrome and extreme thrombocytopenia tend to be recognized earlier in life due to the severity of bleeding. Similarly, syndromic disorders such as Hermansky Pudlak syndrome are readily diagnosed because of the mild bleeding diathesis and associated features such as loss of hair color. In stark contrast, so-called ‘mild’ platelet disorders are both difficult to diagnose and to investigate because of the absence of a gold standard platelet function test and the unclear patent of inheritance. In many cases, notably males, the patient may have not been challenged until adulthood, and the bleeding diathesis undetected. In such cases, it is the experience of the consulting clinician who makes the diagnosis on account of the ‘very mild’ bleeding history and the absence of a defect in other hematological tests.
Thus, there remains an urgent unmet need to develop a definitive assay of platelet function. Next generation sequencing methods are being used increasingly to diagnose a platelet, although in many cases, interpretation is a major challenge. While several new genes have been identified, notably for thrombocytopenia, and cases of autosomal dominance, the molecular basis of bleeding in 50 percent of patients remain undiagnosed, and for some, it remains unclear whether they even have a platelet disorder. Further, many of the new genes only appear to cause platelet dysfunction is a subset of patients.
Accreditation - Attendees may earn up to 18 credits for this course:
The course is suitable for clinicians and scientists who are interested in the investigation of patients and platelet function testing. There will be plenty of time to mingle with other participants and the experts.
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Questions? Email firstname.lastname@example.org.
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