|ISTH e-Newsletter: New SSC Biorheology Subcommittee Project|
New SSC Biorheology Subcommittee Project: Scaling in Hemorheology
The influence of blood flow on thrombus formation is well-recognized, and a variety of in vitro models are available to study flow-related phenomena. However, there are few guidelines for choosing channel geometries, shear rates and assay duration, among other parameters. Moreover, comparing results between models and between laboratories is difficult due to the assortment of flow chambers. The SSC’s Biorheology Subcommittee is beginning a new project to provide recommendations for the use of scaling and dimensionless numbers in describing and analyzing data in flow assays and in vivo models.
The engineering concepts of dimensional and dynamic scaling, and the associated dimensionless numbers that come from these scaling arguments, are a useful way to describe and compare in vitro and in vivo experiments conducted under physiologically-relevant flow conditions. These principles can also be used to design devices and conducting experiments to achieve a desired hemodynamic condition. Some of this terminology has been appearing in the hemostasis literature, including in the JTH, owing to new experimental techniques (e.g. microfluidics) and measurements. This project will provide a primer on these concepts for the non-expert, make recommendations for best practices and carry-out experiments to demonstrate their utility.Click to learn more.