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ISTH Webinar: Hemostatic Complications in Patients on ECMO and VADs
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ISTH Webinar: Hemostatic Complications in Patients on ECMO and VADs

When: Wednesday, August 8, 2018
16:00 UTC

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Hemostatic complications in patients on ECMO and VADs


August 8, 2018 16:00 - 17:00 UTC

(August 8 12:00 EDT)

ISTH Core Curriculum 16.3, 16.4, 23.4, 25.1, 27.3 and 27.4 


Jean Connors "Complications in adult patients"

Katherine Regling "Complications in pediatric patients"


Moderator: Christina VanderPluym, Harvard Medical School (USA)





Jean Connors

Jean M Connors MD is a hematology attending at Brigham and Women’s Hospital and Dana Farber Cancer Institute, the Medical Director of the inpatient Hemostatic Antithrombotic Stewardship program and the outpatient Anticoagulation Management Services, and an associate professor of medicine at Harvard Medical School. She attended Johns Hopkins School of Medicine, did medical residency at Beth Israel Hospital Boston, and completed fellowship training in hematology-oncology at Brigham and Women’s Hospital and in transfusion medicine at the Harvard Joint Program in Transfusion Medicine. Dr. Connors has participated in numerous clinical trials for patients with venous thrombosis, is currently participating in the trials of reversal agents for the direct oral anticoagulants, and is the leading national level trials to study the use of DOAC in cancer associated venous thromboembolism. She works closely with the Hemostatic Antithrombotic Stewardship staff which is responsible for oversight and management of anticoagulation for patients with mechanical circulatory support.

Katherine Regling 

From a young age, Dr. Regling's goal was to become a pediatric hematologist/oncologist after reading a novel about a young girl with leukemia, which many of the adults in her life found to be an astounding career goal for only an eight-year-old child.  As she continued in my training, it became clear that her aspiration would indeed become reality.  She received her Bachelor of Science degree from Michigan State University in Medical Technology, which further sparked her interest in hematology as a large part of the curriculum was based on general hematology concepts and spending a significant portion of the time in the blood bank. She went on to pursue my medical education at Lake Erie College of Osteopathic Medicine in Pennsylvania, and then returned home to complete her residency at Children’s Hospital of Michigan.  Her passion for this field continued to grow as she became exposed to the diverse patient population in Detroit.  She became interested in bleeding disorders after caring for many young girls with menorrhagia. It was this experience that led her to pursue my resident research project in patients with von Willebrand Disease and changes seen on thromboelastography with her mentor, Dr. Meera Chitlur, and she was able to show that components of the thromboelastograph were sensitive to low von Willebrand factor levels. She enjoyed learning about the TEGÒ, which was new and an interesting way to study coagulation. The technology intrigued her and she was excited to see that their data showed that the TEG could identify patients with VWD, and this had not been shown previously. She was able to present her data in poster format at the ASH meeting in 2016 and she also won the resident research award for this project. This definitely worked to solidify her interest in the field of coagulation.

Christina VanderPluym

Dr Christina VanderPluym completed her medical school, Pediatric Residency and Cardiology Fellowship at the University of Alberta and Stollery Children’s Hospital in Edmonton, Canada. In Canada, she was exposed to the initial use of pediatric VADs in North America, starting with early utilization of the Berlin Heart EXCOR, and evolving to use various other forms of mechanical circulatory support in the complex pediatric population. Following this she completed her subspecialty training in Heart Failure and Heart Transplantation at Boston Children’s Hospital. She currently acts as Medical Director of the Ventricular Assist Device Program at Boston Children’s Hospital as well as the Director of the Cardiac Antithrombosis Management Program. She is an assistant professor of Pediatrics in the Harvard School of Medicine. Her clinical and academic interests are related to improving outcomes of VAD related thrombotic complications by evaluating and standardizing anticoagulation practices and applying alternative anticoagulation strategies to the pediatric population. She has also focused her attention to the improving outpatient VAD care for pediatric patients. She has developed a smart phone application that allows patients and providers to interface daily, thereby simplifying and improving communication around daily VAD management and care. Dr VanderPluym has authored multiple peered reviewed publications, chapters, and articles, and continues to present on VAD support and anticoagulation in the pediatric cardiac population around the world.



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