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ISTH Webinar: Protein C Deficiency and Thromboembolism
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ISTH Webinar: Protein C Deficiency and Thromboembolism

When: Wednesday, June 19, 2019
8:00 AM

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Protein C deficiency and Thromboembolism

June 19, 2019 12:00 - 13:00 UTC


Maria DeSancho "Clinical implications of Protein C deficiency"

Leonardo Brandao "Protein C deficiency in children"


Moderator: Yaser Diab


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Maria DeSancho

Dr. DeSancho is a board certified hematologist with special interest in the field of thrombosis and hemostasis. Within her clinical practice she sees many patients referred with either thrombophilia and/or thrombosis. Her main interest within the area of thrombosis is to identify mechanisms of thrombosis in patients with cancer and in patients with estrogen-related thrombosis. Thrombosis is the second cause of death in cancer patients and causes significant morbidity in these patients. Therefore determining biomarkers and coagulation parameters that can help us to identify what cancer patients are at high risk for developing thrombosis will prevent this potential lethal complication.

She cares for many patients with venous thromboembolism (VTE). Her collaborators and herself are in the process of starting an investigator initiated study to assess new state-of-the-art coagulation tests to predict the risk of thrombosis in an individual cancer patient, so that prophylactic anticoagulant therapy can be administered in the future in patients at high risk of thrombosis.

Dr. DeSancho has been researching the risk of thromboembolic events starting at Mount Sinai Medical Center, and now at Weill Cornell Medical Center for many years. Since she sees and cares for many patients with VTE, she is able to contribute to the expansion of a national registry for patients with thrombosis and thrombophilia with the main objective of improving the care of these patients.  

Leonardo Brandao

Dr. Leonardo Brandao is a native Brazilian who obtained his medical degree at University of São Paulo (USP), São Paulo, Brazil and post-graduate training in the USA (Emory Univ./Atlanta; St. Jude Children's Research Hospital/Memphis; Cornell Univ./NYC) before moving to The Hospital for Sick Children, University of Toronto, Ontario, Canada. He is currently a member of the Hemostasis and Thrombosis Service and his main academic interest is Pediatric Thrombosis. As a clinician investigator, he and his team have funded to investigate thrombosis outcomes in children.  

Yaser Diab, MBBS

Dr. Yaser Diab is Medical Director of the Pediatric Thrombosis Program at the Center for Cancer and Blood Disorders at The Children’s National Health System in Washington, DC, USA and Assistant Professor of Pediatrics at the George Washington University School of Medicine and Health Sciences in Washington, DC, USA.  

After completing his medical training at the University of Jordan in Amman, Jordan, Dr. Diab pursued subspecialty training in pediatrics at The Children's Hospital at SUNY Downstate in Brooklyn, NY, USA. After finishing his pediatric residency training, Dr. Diab completed a fellowship training in pediatric hematology/oncology at The Children’s National Health System in Washington, DC, USA followed by a pediatric thrombosis and hemostasis fellowship at The Hospital for Sick Children in Toronto, Canada. 

Dr. Diab's research interests are focused on developing effective strategies for treatment and prevention of venous thrombosis in pediatric patients. As the thrombosis program director at Children’s National Health System, Dr. Diab led a rapid expansion of the program services which now includes both an inpatient thrombosis consult service and a comprehensive thrombosis and anticoagulation clinic. He also developed an effective institutional surveillance system for real-time identification of thromboembolic events using natural language processing and established a robust institutional thrombosis patient registry created using Research Electronic Data Capture (REDCap) that is maintained prospectively which has provided valuable information that guided multiple institutional quality improvement initiatives.  


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