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ISTH Webinar: Protein C Deficiency and Thromboembolism
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ISTH Webinar: Protein C Deficiency and Thromboembolism

 Export to Your Calendar 6/19/2019
When: Wednesday, June 19, 2019
8:00 AM

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Protein C deficiency and Thromboembolism

June 19, 2019 12:00 - 13:00 UTC


Edelgard Lindhoff-Last "Pathophysiology of the protein C pathway and role in haemostasis"

Maria DeSancho "Clinical implications of Protein C deficiency"


Moderator: Yasir Diab


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Prof. Dr. med. Edelgard Lindhoff-Last

Head of the Coagulation Research Center and the Coagulation Center  
Member of the Vascular Center 
at the Cardioangiology Center Bethanien (CCB), Frankfurt, Germany

Edelgard Lindhoff-Last became Head of the Coagulation Research Center and of the Coagulation Center at the Cardioangiology Center Bethanien in January 2015, where she works as a specialist in internal medicine, focusing on angiology and haemostasis.

Prior to this appointment, Prof. Lindhoff-Last spent her career at Johann-Wolfgang Goethe-University, Frankfurt, Germany, beginning as a physician in 1987 and progressing to Fellow, Consultant, and Associate Professor, before becoming Professor of Angiology and Haemostaseology in 2008. From 2004 – 2014 she was head of the department of Angiology and Haemostaseology at the Johann-Wolfgang Goethe University Hospital, Frankfurt, Germany.  During her career, she has amassed 18 years of experience in clinical trials and -  in addition to her clinical and scientific work - was responsible for the coagulation laboratory. Prof. Lindhoff-Last is a  member of the board of directors of the Gesellschaft für Thrombose- und Hämostaseforschung (GTH; Society of Thrombosis and Hemostasis Research),a  member of the International Society of Thrombosis and Haemostasis (ISTH), and a board member of the ISTH subcommittee Control of Anticoagulation. She is also a member of the German societies of Angiology, Internal Medicine, Cardiology and the European Society of Cardiology.Her many research interests include monitoring of direct oral anticoagulants and their influence on coagulation assays ex vivo as well as  documentation of bleeding management in anticoagulated patients in prospective  registries or improving thrombophilia testing.

Maria DeSancho

Dr. DeSancho is a board certified hematologist with special interest in the field of thrombosis and hemostasis. Within her clinical practice she sees many patients referred with either thrombophilia and/or thrombosis. Her main interest within the area of thrombosis is to identify mechanisms of thrombosis in patients with cancer and in patients with estrogen-related thrombosis. Thrombosis is the second cause of death in cancer patients and causes significant morbidity in these patients. Therefore determining biomarkers and coagulation parameters that can help us to identify what cancer patients are at high risk for developing thrombosis will prevent this potential lethal complication.

She cares for many patients with venous thromboembolism (VTE). Her collaborators and herself are in the process of starting an investigator initiated study to assess new state-of-the-art coagulation tests to predict the risk of thrombosis in an individual cancer patient, so that prophylactic anticoagulant therapy can be administered in the future in patients at high risk of thrombosis.

Dr. DeSancho has been researching the risk of thromboembolic events starting at Mount Sinai Medical Center, and now at Weill Cornell Medical Center for many years. Since she sees and cares for many patients with VTE, she is able to contribute to the expansion of a national registry for patients with thrombosis and thrombophilia with the main objective of improving the care of these patients.  

Yaser Diab, MBBS

Dr. Yaser Diab is Medical Director of the Pediatric Thrombosis Program at the Center for Cancer and Blood Disorders at The Children’s National Health System in Washington, DC, USA and Assistant Professor of Pediatrics at the George Washington University School of Medicine and Health Sciences in Washington, DC, USA.  

After completing his medical training at the University of Jordan in Amman, Jordan, Dr. Diab pursued subspecialty training in pediatrics at The Children's Hospital at SUNY Downstate in Brooklyn, NY, USA. After finishing his pediatric residency training, Dr. Diab completed a fellowship training in pediatric hematology/oncology at The Children’s National Health System in Washington, DC, USA followed by a pediatric thrombosis and hemostasis fellowship at The Hospital for Sick Children in Toronto, Canada. 

Dr. Diab's research interests are focused on developing effective strategies for treatment and prevention of venous thrombosis in pediatric patients. As the thrombosis program director at Children’s National Health System, Dr. Diab led a rapid expansion of the program services which now includes both an inpatient thrombosis consult service and a comprehensive thrombosis and anticoagulation clinic. He also developed an effective institutional surveillance system for real-time identification of thromboembolic events using natural language processing and established a robust institutional thrombosis patient registry created using Research Electronic Data Capture (REDCap) that is maintained prospectively which has provided valuable information that guided multiple institutional quality improvement initiatives.  


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