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ISTH Webinar: Mouse Models of Thrombosis
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ISTH Webinar: Mouse Models of Thrombosis

When: Wednesday, December 11, 2019
14:00 UTC

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Mouse Models of Thrombosis

December 11, 2019 14:00 - 15:00 UTC


Beatrice Hechler "Laser injury models"

  • Characterization of a model of Laser-induced thrombosis in mouse mesenteric arterioles with moderate and severe levels of injury: damage to the vessel wall and in particular the exposed matrix proteins, the structure of the thrombus explored by histological methods and electron and intravital microscopy.
  • Comparison to other Laser-injury models performed in cremaster arterioles.

Brian C. Cooley "Examples of in vivo thrombosis mouse models"

  • Participants will learn to understand comparative differences and similarities among various mouse models of thrombosis.
  • Participants will learn to make appropriate selection of in vivo thrombosis models for specific study designs and goals.


Moderator: Caterina Casari


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Beatrice Hechler

Beatrice Hechler gained her Ph.D. in Pharmacology in 1998 at the Université Louis Pasteur, Strasbourg, France. She became a Researcher at INSERM (Institut National de la Santé et de la Recherche Médicale) in 2000. She is currently working in the INSERM Unit 1255 "Biology and pharmacology of blood platelets: haemostasis, thrombosis, transfusion" located at the Etablissement Français du Sang-Grand Est directed in Strasbourg, France, directed by Dr. Christian Gachet.

The main focus of Beatrice Hechler’s work is platelet biology, pathophysiology and pharmacology and some aspects of vascular biology. Her main interest has long been the molecular mechanisms of ADP-induced platelet activation and its inhibition by the thienopyridine compounds. This led to the characterization and the identification of some of the platelet P2 receptors. She carried out extensive work on the platelet P2Y1 and P2X1 receptors. She also acquired expertise in various mouse models of arterial thrombosis in healthy murine vessels as well as in a context of atherosclerosis. Beatrice Hechler is currently interested in evaluating the role of platelets in non-haemostatic functions including septic shock, anaphylaxis and acute lung injury following transfusion of a blood product (TRALI). Since 2019, she has been appointed for a 4-year term as a Co-Chairman of the ISTH Scientific and Standardization Subcommittee on Models of Thrombosis and Hemostasis. 


Brian C. Cooley

Brian C. Cooley, the Director of the Animal Surgery Core Laboratory and an Associate Professor at the University of North Carolina – Chapel Hill.  He has extensive experience with mouse, rat, and other animal surgical and microsurgical models, with a main focus on studies of thrombosis and hemostasis.  He has developed several novel models for evaluating arterial and venous thrombosis, primarily in murine systems.  Through a grant from the National Institute of Biomedical Imaging and Bioengineering, he designed a customized intravital fluorescence imaging and video capture system for imaging murine large-vessel thrombosis, which has been used for in vivo experiments in over 20 peer-reviewed publications.  He has served as a reviewer for most of the major journals in the field and has over 120 peer-reviewed publications, including Nature Medicine and Science Translational Medicine.


Caterina Casari

Caterina is an Italian molecular biologist with extensive experience in the field of haemostasis. Her introduction to the field occurred during her Master’s degree studies at the University of Ferrara (Italy) in the laboratory of Prof. Francesco Bernardi. Under his mentorship, she obtained her Ph.D. in Biochemistry, Molecular Biology and Biotechnology with a thesis focused on von Willebrand Factor (VWF). Fascinated by the biochemical features and by the many pathophysiological roles of VWF, she moved to Paris for her first post-doctoral experience. She joined the team of Drs. Cécile Denis, Peter Lenting and Olivier Christophe where she strengthened her expertise on VWF and acquired experience with in vivo mouse models. While investigating several molecular pathways resulting in von Willebrand Disease type 2B, a paradoxical bleeding disorder associated with thrombocytopenia, she extended her curiosity and efforts to platelet biology and platelet-associated disorders. In 2014, she was awarded a three-year Non-clinical Junior Research Fellowship by the European Hematology Association to join the group of Prof. Wolfgang Bergmeier at the McAllister Heart Institute (University of North Carolina in Chapel Hill, USA). In 2016 she returned to INSERM in Paris where she was selected as researcher (Chargé de recherche de classe normale) in 2018. Currently, she is part of the Inserm Unit 1176 -Hemostasis, Inflammation, Thrombosis- and her research studies are predominantly focused on VWF and its partners. She is interested in developing in vitro & in vivo models to elucidate molecular mechanisms underlying the unsolved clinical aspects of congenital and acquired von Willebrand disease. She is also interested in exploring novel molecular strategies that can be applied as therapeutic approaches for VWF-associated disorders. She has been a member of the ISTH-Early Career Committee since its creation in 2013 (vice-chair 2018-2019 and future Chair in 2020).


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