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ISTH Webinar: Pathways in Thrombosis and Hemostasis
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When: Wednesday, March 18, 2020
13:00 UTC

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Pathways in Thrombosis and Hemostasis

March 18, 2020 13:00 - 14:00 UTC (9:00 EST)


Alisa Wolberg "Fibrinogen/clot structure and composition"

Participants in this session will be able to:

  • Describe basic biology of fibrinogen and its conversion to fibrin.
  • Describe mechanisms by which fibrin and fibrin crosslinking mediate thrombus formation and composition. 

Helen Philippou "The contact pathway as an antithrombotic target"

Participants in this session will be able to:

  • Understand why the contact pathway has become attractive as an anticoagulant target.
  • Understand current approaches to address unmet clinical needs of anticoagulation.


Moderator: Evi Stavrou


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Helen Philippou

Professor Helen Philippou (HP) is Professor of Translational Medicine in the Faculty of Medicine and Health at the University of Leeds and Founder Director of LUNAC Therapeutics Ltd (a spin-out company form the University developing a novel anticoagulant). Professor Philippou moved to the University of Leeds in 2002 following a 10 year career at Imperial College London. Prof Philippou is on the Editorial Board RPTH Journal,  is the Scientific Secretary for the British Society of Haemostasis and Thrombosis (BSHT) Society Committee (since 2016), Co-Chair for the FXI and Contact System SSC of the ISTH (since 2018), Member of the International Advisory Board for the ISTH 2020/2021 Congress (Milan/Philadelphia) and a member of the Local Organization Committee for ISTH Society for the meeting in London in 2022. Previously she was Chairman for the FXIII and Fibrinogen Scientific Subcommittee (SSC) of the International Society of Thrombosis and Haemostasis (ISTH) (2012-2016). Since arriving at the University of Leeds in 2002, Prof Philippou has been responsible for raising >£15m grant income with ~£10m as Principal Investigator. 

Alisa Wolberg

Alisa S. Wolberg, PhD FAHA is a graduate of the University of North Carolina at Chapel Hill (UNC, BS ’91, PhD ’96), and is currently Professor of Pathology and Laboratory Medicine with tenure at UNC. Dr. Wolberg’s expertise is in physiologic and pathophysiologic mechanisms in hemostasis and thrombosis, including in vitro and in vivo models of bleeding and thrombotic disorders. Ongoing work in her laboratory includes studies on contributions of fibrin(ogen), factor XIII, and red blood cells to thrombosis, role of female hormones and oral contraceptives in venous thromboembolism, mechanisms in cancer-associated thrombosis, and elucidating mechanisms that mediate clot formation and stability in hemophilia A and B and factor XI deficiency (hemophilia C). Dr. Wolberg is the Director of UNC’s T32 and Program in Translational Medicine. She is also a member of the governing Council of the International Society of Thrombosis and Haemostasis (ISTH), and Vice-Chair of the Committees on Membership/Communications and Governance. She also serves on the Board of Directors of the Hemostasis and Thrombosis Research Society and Board of Counsillors of the International Fibrinogen Research Society. Dr. Wolberg is an Associate Editor for Research and Practice in Thrombosis and Haemostasis and serves on the editorial boards for Arteriosclerosis, Thrombosis, and Vascular BiologyBloodBlood Advances, and the Journal of Thrombosis and Haemostasis. She is also a member of the American Society of Hematology (ASH) Committees on Scientific Affairs, Media Experts, and Dynamic Research, working groups on Women in Hematology and Hemostasis and Thrombosis, chairs the ASH task force on the PhD workforce in hematology, and will co-chair the 2020 ASH Annual Meeting. 

Evi Stavrou

Dr. Evi X. Stavrou is the Oscar D. Ratnoff Professor of Medicine and Hematology at Case Western Reserve University and Staff Hematologist and Director of Anticoagulation Clinic at the Louis Stokes Cleveland VA Medical Center. She received her MD degree summa cum laude from Semmelweis University in Budapest, Hungary. On completion of her medical school training, Dr. Stavrou completed her Internal Medicine residency at Johns Hopkins University-Sinai program and Hematology-Oncology fellowship at University Hospitals Case Medical Center.

Presently, her work is focused on the Factor XII – uPAR interactome and neutrophil cell biology in health and disease. Her lab’s main research interests are in i) structural biochemical characterization of protein-protein interactions, ii) microfluidic design and development to study neutrophil functions and thrombus characteristics, iii) small molecule peptide development to selectively abrogate FXII-mediated responses, and iv) disease-targeted drug delivery systems. The areas of focus are pathologic states where primed-activated neutrophils contribute to disease namely chronic, non-healing diabetic wounds, deep vein thrombosis, and cancer progression. Her work has been published in premier journals including Blood, the Journal of Thrombosis and Haemostasis, Nature Communications and the Journal of Clinical Investigation. She serves as associate editor of the journal Frontiers in Hematology, is Co-Chair of the HTRS Publications Committee and was previously a Co-Chair of the ISTH-SSC Sub-Committee on FXI and the Contact System. Dr. Stavrou’s work was previously funded by the Hemostasis and Thrombosis Research Society and subsequently, from the American Heart Association. Presently, Dr. Stavrou is funded by the National Institutes of Health, VA Research & Education Foundation and VA Advanced Platform Technology Center. Her clinical duties are solely focused on patients with hemostatic and thrombotic disorders.


Supported by Instrumentation Laboratory.

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