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ISTH Academy Webinar: Considerations in the Measurement of Extended Half-Life Factor Products
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ISTH Academy Webinar: Considerations in the Measurement of Extended Half-Life Factor Products

When: Wednesday, September 20, 2017
15:00 UTC/GMT

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Considerations in the Measurement of Extended Half-life Factor Products


ISTH Core Curriculum 2.2 – Laboratory Practice, 8.1 – Rarer Bleeding Disorders

September 20, 2017 15:00 - 16:00 UTC


Steve Kitchen "Measurement of novel and extended half-life FVIII products"

Stefan Tiefenbacher "Measurement of the extended half-life FIX products "

Moderator: Annette Bowyer, Royal Hallamshire Hospital (UK)


Measurement of novel and extended half-life FVIII products - Steve Kitchen

In this presentation, Professor Kitchen will provide a review of chromogenic and one stage FVIII assay data with different kits and reagents for monitoring 3 different pegylated FVIII molecules, Fc Fusion FVIII and  a novel single chain recombinant FVIII to clarify the options available to laboratories.


  • Understand assay related differences  in FVIII activity.
  • Understand use of chromogenic FVIII assay for monitoring EHL and novel FVIII molecules.
  • Understand one stage assay issues when monitoring these products.

Target audience

  • Clinicians responsible for haemophilia patients
  • Lab scientists in haemophilia centre laboratories
  • Other health care professionals dealing with haemophilia monitoring
  • Colleagues in pharma working in haemophilia care



Steve Kitchen
Dr. Steve Kitchen is the lead scientist in the department of Coagulation atSheffield Haemophilia and Thrombosis Centre, Sheffield Teaching Hospitals. The centre is designated an International Haemophilia Training Centre by World Federation of Haemophilia. In addition he serves as Scientific Director of theUK National External Quality Assessment Schemefor Blood Coagulation and Director of the World Federation of Hemophilia'sInternational External Quality Assessment Schemes for Blood Coagulation.He also serves on numerous working groups and committees including the Steering Committee forSteering committee UK NEQAS Blood Coagulationand as Associate Editor of theJournal of Thrombosis and Haemostasis.He has previously served on the ISTH Education Committee and as an Associate Editor forSeminars in Haemostasis and Thrombosis.


Stefan Tiefenbacher
Dr. Stefan Tiefenbacher is the Vice President of Laboratory Corporation of America® Holdings and the Technical Director of Coagulation, Colorado Coagulation, A LabCorp Speciality Testing Group. Dr Tiefenbacher earned his PhD in Neuroscience and Behavior at the University of Massachusetts in 2002. He completed fellowships in Psychiatry and Pharmacology at Harvard Medical School and the University of Colorado Health Sciences Center. Dr Tiefenbacher joined the Colorado Coagulation team as Scientific Director in 2005, where he directs and oversees the scientific and technical aspects of clinical and clinical trial testing, as well as assay development and validation. Dr Tiefenbacher has more than 10 years of experience in assay validation in both the bioanalytical, as well as good clinical practice (GCP) setting. He is an active contributor at the Clinical Laboratory Standards Institute (CLSI) and a member of the International Society on Thrombosis and Haemostasis and the World Federation of Hemophilia.


Annette Bowyer
Annette Bowyer is the lead Biomedical Scientist for the Haemophilia Assays section in the Department of Coagulation at Sheffield Haemophilia and Thrombosis Centre. The Centre is a designated International Haemophilia Training Centre by the World Federation of Haemophilia. Dr Bowyer was awarded her PhD in Cardiovascular Science from the University of Sheffield with a thesis focusing on the laboratory diagnosis of mild Haemophilia A. She has more than 15 years experience in the diagnosis and monitoring of bleeding disorders with a current interest in laboratory issues surrounding extended half-life treatment products for Haemophilia. Dr Bowyer is a fellow of the Institute of Biomedical Science and member of the International Society on Thrombosis and Haemostasis and the World Federation of Haemophilia.


Supported by an unrestricted educational grant from Bioverative and Sobi.


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