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2015 Annual Minutes
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6/21/2015 at 3:54:15 PM GMT
Posts: 80
2015 Annual Minutes

Chairman: Alok A. Khorana

Co-Chairs: Marc CarrierHoward A. LiebmanNigel MackmanSimon NobleIngrid PabingerJoseph S. Palumbo

 Education Session

The education session was chaired by Dr.s Khorana and Carrier and included Dr.s Carrier and Noble as speakers.  Dr. Carrier spoke about occult malignancy screening after unprovoked VTE, particularly in light of two trials to be presented at ISTH 2015. Although results of these studies were not yet available, Dr Carrier identified study design and expectations for outcomes. He proposed a guidance statement from SSC of ISTH after results of these studies are known to better inform hematologists on practice issues. Dr. Noble provided an overview of qualitative research in hematology, how it differs from generally accepted standards and sample sizes in quantitative research and how it can inform patient care.

 SSC Working Session

The session was first chaired by Dr.s Mackman and Pabinger. The second half was chaired by Dr.s Ay and Zwicker. Dr.s Palumbo, Mackman and Pabinger described recent results linking platelet activation with hemostatic factors and tumor biology. Dr. Mackman posed the question of how therapeutic targeting of platelets could affect malignancy outcomes and potentially even prevent thrombosis in this setting. Dr. Khorana reviewed recent data regarding clinical predictors and biomarkers of recurrent VTE in malignancy, in context of the recent completed CATCH study. Dr. Falanga described early findings and study design of an Italian study of biomarker screening for cancer-associated thrombosis, the HYPERCAN study. Dr. O’Connell described emerging data regarding prevalence and outcomes related to incidental thrombosis in malignancy. She was followed by Dr. Di Nisio who presented the new ISTH guidance statement on incidental thromboembolism in malignancy, recently published in JTH. Dr. Ay described how network analysis could evaluate anticoagulants in different clinical trials indirectly. Dr. Othman presented data suggesting a strong hypercoagulable state in prostate cancer. Dr. Zwicker presented data on intracranial bleeding in patients with brain metastases and a guidance proposal to better categorize such bleeds in future studies. Dr. Palumbo described draft guidance statement proposal encompassing venous thromboembolism in pediatric cancer patients. Finally, Dr Kamphuisen provided an update on the LONGHEVA trial which has now transformed into an online registry and asked for SSC members to participate. The session was adjourned at 6.40 PM.

Last edited Tuesday, August 18, 2015
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