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New Recommendations and Guidelines from the SSC of the ISTH

Friday, August 1, 2014   (0 Comments)
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Now available online in JTH!

An International Collaborative Study to establish the WHO 2nd International Standard for Factor VII Concentrate; communication from the SSC of the ISTH

Craig Thelwell, Peter Rigsby, Sally Bevan and Malinee Beeharry

The 1st International Standard (IS) for factor VII concentrate (97/592) was established by the Expert Committee on Biological Standardisation (ECBS) of the World Health Organization (WHO) in 1998 [1]. A potency of 6.3 IU was assigned to the preparation by clotting and chromogenic methods, relative to the 2nd IS factors II, VII, IX, X plasma (94/746) and normal plasma pools. This reference material has been used for potency assignment to human coagulation FVII concentrate preparations used to treat FVII deficiency, and for FVII-containing prothrombin complexes used for reversal of anticoagulant treatment. As stocks of the 1st IS are low, an international collaborative study was organised to calibrate a replacement.

Accepted manuscript online: 23 JUL 2014 10:13AM EST | DOI: 10.1111/jth.12671

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