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New Recommendations and Guidelines from the SSC Subcommittee on Hemostasis & Malignancy

Tuesday, September 9, 2014   (0 Comments)
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Evaluation of a New Commercial Assay to Measure Microparticle Tissue Factor Activity in Plasma: communication from the SSC of the ISTH

K. Tatsumi, S. Antoniak, D. M. Monroe III, A A. Khorana, N. Mackman and the Subcommittee on Hemostasis and Malignancy

Microparticles (MPs) are small membrane vesicles that are released by activated cells, such as monocytes, cells undergoing apoptosis and tumor cells [1]. Full-length tissue factor (flTF) is a transmembrane receptor for FVII/VIIa and is essentially undetectable in the blood of healthy individuals. However, intravascular levels of flTF are increased in a variety of diseases, including cancer and endotoxemia [1]. The majority of active flTF in plasma in these disease states is present on MPs.

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