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JTH Releases SSC Recommendation on Measuring Thrombin Generation in Hemophilia

Wednesday, August 2, 2017   (0 Comments)
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The Journal of Thrombosis and Haemostasis (JTH) has accepted the following articles on recommendations from the Scientific and Standardization Committee (SSC) of the ISTH:

Subcommittee on Factor VIII, Factor IX and Rare Coagulation Disorders
Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia

Readouts from the thrombin generation (TG) assay (TGA) have been used to predict the effects of hemostatic drugs in hemophilic patients [1]. There is better correlation between an individual's bleeding tendency and his or her TG capacity compared with factor levels measured using routine assays [2, 3]. However, the clinical utility of TGA has not yet been validated in multicenter studies because of lack of standardization. This report aims to highlight variables that may impact directly on TGA reliability and steps to reduce TGA variability within and between laboratories to improve precision of results. Read more.

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