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News & Press: Press Releases

The ISTH Publishes First Clinical Practice Guidelines for Thrombotic Thrombocytopenic Purpura

Wednesday, July 15, 2020   (0 Comments)
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CHAPEL HILL, NC, USA, (July 16, 2020) — The International Society on Thrombosis and Haemostasis (ISTH) has published new clinical practice guidelines for the diagnosis and treatment of thrombotic thrombocytopenic purpura (TTP). Developed in partnership with McMaster University, the ISTH TTP Guidelines are the product of a rigorous, systematic review of evidence by a guideline panel comprised of clinical experts, methodologists and patient representatives.

TTP is a rare, life-threatening thrombotic microangiopathy or blood disorder. In TTP, blood clots form in small blood vessels throughout the body and can limit or block the flow of oxygen-rich blood to the body’s organs, such as the brain, kidneys and heart. This can result in serious health problems. The reported incidence of TTP is two to six cases per million per year and a mortality of 10-20 percent upon proper treatment.

The challenge is that there are a number of conditions that have clinical and laboratory presenting features similar to those of TTP. A number of new therapeutic agents have been developed, requiring detailed guidance to properly manage treatment. The ISTH TTP Guidelines provide important recommendations, which will improve the management of patients with TTP.

The ISTH TTP Guideline panel was co-chaired by X. Long Zheng, M.D., Ph.D., of the University of Kansas (U.S.) and Sara K. Vesely, Ph.D., of the University of Oklahoma (U.S.).
“With this first ISTH guideline for care of patients with TTP, it is time for everyone to become a TTP expert,” Zheng said. “The guideline panel reviewed the available evidence, making it easier for clinicians to make informed care decisions for their patients.”

“These high quality guidelines will be valuable for health care providers who diagnosis and manage both immune and congenital TTP,” Vesely added.

McMaster University in Canada served as a consultant on the project, providing critical methodological expertise in clinical practice guideline development. Long-time ISTH members Alfonso Iorio, M.D., Ph.D., and Menaka Pai, M.D., led the methodology team at McMaster.

The guideline development process adhered to the recommendations outlined in the Institute of Medicine’s Clinical Practice Guidelines We Can Trust.

Review the ISTH TTP Guidelines here.

See the full guideline panel below:
Co-Chair: X. Long Zheng, M.D., Ph.D. (U.S.)
Co-Chair: Sara K. Vesely, Ph.D. (U.S.)
Spero Cataland, M.D. (U.S.)
Paul Coppo, M.D. (France)
Masanori Matsumoto, M.D., Ph.D. (Japan)
Reem Mustafa, Ph.D. (U.S.)
Flora Peyvandi, M.D., Ph.D. (Italy)
Gail Rock, M.D., Ph.D. (Canada)
Lene Russell, M.D., Ph.D. (Denmark)
J. Evan Sadler, M.D., Ph.D. (U.S.)
Rawan Tarawneh, M.D. (U.S.)

Patient representatives:
Julie Valdes (U.S.)
Brian Geldziler (U.S.)
Lauren Ruiz (U.S.)


About the ISTH

Founded in 1969, the ISTH is the leading worldwide not-for-profit organization dedicated to advancing the understanding, prevention, diagnosis and treatment of conditions related to thrombosis and hemostasis. ISTH is an international professional membership organization with more than 5,000 clinicians, researchers and educators working together to improve the lives of patients in more than 100 countries around the world. Among its highly regarded activities and initiatives are education and standardization programs, clinical guidance and practice guidelines, research activities, meetings and congresses, peer-reviewed publications, expert committees and World Thrombosis Day on October 13. Visit ISTH online at


Media Contact

Louise St. Germain

Director of Marketing, Membership and Public Affairs

International Society on Thrombosis and Haemostasis

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