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ISTH Partners with McMaster University to Publish a Guideline on Thrombotic Thrombocytopenic Purpura

Wednesday, April 25, 2018   (0 Comments)
Posted by: Barbara Krolak
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CHAPEL HILL, NC, USA – April 25, 2018 – The International Society on Thrombosis and Haemostasis (ISTH), a global not-for-profit advancing the understanding, prevention, diagnosis and treatment of thrombotic and bleeding disorders, together with McMaster University, today announced a partnership to publish a Guideline on Thrombotic Thrombocytopenic Purpura (TTP). This comprehensive guideline will address diagnosis, prognosis and treatment of TTP and will include a systematic review of existing protocol to improve patient outcomes around the world.

TTP is a rare, life-threatening thrombotic microangiopathy or blood disorder. In TTP, blood clots form in small blood vessels throughout the body and can limit or block the flow of oxygen-rich blood to the body’s organs, such as the brain, kidneys and heart. This can result in serious health problems. The reported incidence of TTP is two to six cases per million per year and a mortality of 10-20 percent upon proper treatment. The challenge is that there are a number of conditions that have clinical and laboratory presenting features similar to those of TTP.  A number of new therapeutic agents have been developed, requiring detailed guidelines to improve the management of patients with TTP. 

"When embarking on an important guideline, such as one on TTP, it's important to partner with an organization like McMaster University that has an international reputation and expert credibility for its work in clinical practice guideline work," said Ingrid Pabinger, Chairman, ISTH Council. "McMaster University, specifically Dr. Alfonso Iorio from McMaster's Department of Health Evidence and Information and Dr. Menaka Pai from the McMaster Centre for Transfusion Research, will work closely with leaders from the ISTH Guideline Panel, including Clinical Co-Chair Dr. J. Evan Sadler from Washington University Medical School (USA) and Methods Co-Chair Dr. Sara Vesely from the University of Oklahoma (USA). Together they will offer practical, evidence based recommendations to support clinical decision making and improving patient care."

The goal of this effort is to create formal recommendations to address questions by clinicians, patients and policy makers on TTP management. An international panel of experts, methodologists and patients will develop these recommendations on diagnosis and treatment.

“We look forward to partnering with ISTH to develop a rigorous, evidence-based clinical practice guideline,” said Dr. Pai.  “As clinicians, Dr. Iorio and I appreciate how TTP impacts patients and families. We are excited to bring our methodologic expertise to this work, and contribute to a set of practical recommendations that will serve the needs of patients and health care providers.”

To begin, an ISTH TTP scoping panel has developed and prioritized guideline questions and potential outcomes. The guideline panel will then further refine these questions to address real life issues the stakeholders face every day. The panel will work with patient organizations and representatives to guarantee importance is placed on how these guidelines will ultimately affect patient health outcomes. 

After the questions are finalized, McMaster will conduct a systematic review of the literature. In line with NGC, Institute of Medicine (IOM) and GRADE standards for guideline development, the foundation will be built upon transparent processes for assessing the quality of evidence and developing recommendations. The guideline will be published in 2019. 

About the ISTH
Founded in 1969, the ISTH is the leading worldwide not-for-profit organization dedicated to advancing the understanding, prevention, diagnosis and treatment of thrombotic and bleeding disorders. ISTH is an international professional membership organization with more than 5,000 clinicians, researchers and educators working together to improve the lives of patients in more than 94 countries around the world. Among its highly regarded activities and initiatives are education and standardization programs, research activities, meetings and congresses, peer-reviewed publications, expert committees and World Thrombosis Day on 13 October. Visit ISTH online at www.isth.org.

Media Contact
Barbara Krolak, Relationship and Campaign Senior Specialist 
International Society on Thrombosis and Haemostasis
+1 919-929-3807
Barbara_Krolak@isth.org 

 

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