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JTH Editors' Awards
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The JTH Editors' Awards are awarded in honor of Pier M. Mannucci, the first Editor-in-Chief of the Journal of Thrombosis and Haemostasis (JTH), for the best articles submitted by early career investigators. The prizes are selected by a jury of editors. Recipients receive a travel grant to an ISTH Congress. To be considered for the next awards, be sure to mark your interest at the time of submission of your manuscript.


Kasper Adelborg
Cardiovascular and bleeding outcomes in a population-based cohort of patients with chronic immune thrombocytopenia

Awital Bar Barroeta
Hydrogen-deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

Maha AT Elsebaie
Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis

Lauren G. Poole
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) cross-linking via tissue transglutaminase

Florian Thibord
A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process

Jospeh Shaw
Periprocedural interruption of anticoagulation in patients with cancer-associated venous thromboembolism: An analysis of thrombotic and bleeding outcomes



Annika de Jong
Correction of a dominant-negative von Willebrand factor multimerization defect by small interfering RNA-mediated allele-specific inhibition of mutant von Willebrand factor

Alev Karasu
Aging of the venous valves as a new risk factor for venous thrombosis in the elderly: the BATAVIA study

Andaleb Kholmukhamedov
The mitochondrial calcium uniporter regulates procoagulant platelet formation

Xinren Yu
Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions



Eimar Gleeson
A novel protein C–factor VII chimera provides new insights into the structural requirements for cytoprotective protease‐activated receptor 1 signaling

Lisa-Marie Mauracher  
Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients

Irina Portier 
High and longterm von Willebrand factor expression after Sleeping Beauty transposonmediated gene therapy in a mouse model of severe von Willebrand disease

Elien Roose 
An open conformation of ADAMTS13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura

Joep Sins 
Dynamics of von Willebrand factor reactivity in sickle cell disease during vasoocclusive crisis and steady state

Alice Van Velzen  
Intensity of factor VIII treatment and the development of inhibitors in nonsevere hemophilia A patients: results of the INSIGHT case–control study



Janneke Loomans
Variation in baseline factor VIII concentration in a retrospective cohort of mild/moderate hemophilia A patients carrying identical F8 mutations

C. Ernesto Fernandez-Garcia
Association of ficolin-3 with abdominal aortic aneurysm presence and progression

Christopher Molloy
Shear sensitive nanocapsule drug release for site specific inhibition of occlusive thrombus formation

Alison Michels
Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis

Kieron South
Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity


Peter Allan, Tyne and Wear, UK, University of Leeds
Evidence that Fibrinogen g’ Directly Interferes with Protofibril Growth: implications for Fibrin Structure and Clot Stiffness

Yuji Kasiwakura, Tochigi, Japan, Dkkyo Medical University
Intra-Articular Injection of Mesenchymal Stem Cells Expressing Coagulation Factor Ameliorates Hemophilic Arthropathy in Factor VIII-Deficient Mice

Janine van Loon, Schiedam, the Netherlands, Erasmus University Medical Centre
Von Willebrand Factor Plasma Levels, Genetic Variations and Coronary Heart Disease in an Older Population

Leslie Skeith, London, Ontario, Canada, London Health Sciences Centre
Conservative Perioperative Anticoagulation Management in Patients with Chronic Venous Thromboembolic Disease: A Cohort Study

John Welsh, Philadelphia, PA, USA, University of Pennsylvania
Platelet-Targeting Sensor Reveals Thrombin Gradients Within Blood Clots Forming in Microfluidic Assays and in Mouse


Firdos Ahmad, Philadelphia, PA, USA
Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.

Maarten Louis Veronique Hendrickx, Leuven, Belgium
TAFIa inhibiting nanobodies as profibrinolytic tools and discovery of a new TAFIa conformation.

Jonas Bjerring Olesen, Copenhagen, Denmark
Bleeding risk in ‘real world’ patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort.

Morten Schmidt, Aarhus, Denmark
Non-steroidal anti-inflammatory drug use and risk of venous thromboembolism.

Christian Schulz, London, UK
EMMPRIN (CD147/basigin) mediates platelet–monocyte interactions in vivo and augments monocyte recruitment to the vascular wall.

Wendy Zondag, Delfgauw, The Netherlands
Outpatient treatment in patients with acute pulmonary embolism: the Hestia Study


Kim Marieke Baeten
Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets.

Sofia Barbar
A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score.

Matteo Bonzini
Effects of inhalable particulate matter on blood coagulation.

Judith M.E.M. Cosemans
Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization.

Stuart Michael Ellison
CD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases.

Hendrik B Feys
Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

Megumi Takiguchi
Transgenic, inducible RNAi in megakaryocytes and platelets in mice.


Carsten Baldauf
Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis

Meganathan Kannan
Molecular defects in ITGA2B and ITGB3 genes in patients with Glanzmann thrombasthenia.

Tatiana Carneiro-Lobo
Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model

Adam Rose
Warfarin dose management affects INR control

Jianguo Wang
Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice


M Coppens
Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis

AF Paes Leme
Bothrops protease A, a unique highly glycosylated serine proteinase, is a potent, specific fibrinogenolytic agent

JG Tardos
SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells

X-L Zhang
Modulation of immune response with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin-induced anergic T cells in chronic idiopathic thrombocytopenic purpura


SDJ Calaminus
MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability

E Ceresa
Comparative evaluation of stable TAFIa variants: importance of α-helix 9 and β-sheet 11 for TAFIa(in)stability

SC Gouw
Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A

Y Kozuma
Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL

HL Lemmerhirt
Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model

X Zheng
Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia


VY Bogdanov
Identification and characterization of murine alternatively spliced tissue factor

J Cho
Characterization of Fibronectin Assembly by Platelets Adherent to Adsorbed Laminin-111

HB Feys
ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences

M Sohne
Accuracy of clinical decision rule, D-dimer and spiral computed tomography in patients with malignancy, previous venous thromboembolism, COPD, heart failure or older patients with suspected pulmonary embolism

RL Varcoe
The role of the fibrocyte in intimal hyperplasia


Ivan Bank
Elevated levels of FVII:C within families are associated with an increased risk for venous and arterial thrombosis

Raquel Barba Martin
The influence of extreme body weight on clinical outcome of patients with venous thromboembolism: Findings from a prospective registry (RIETE)

Kathleen Brummel-Ziedins
The plasma hemostatic proteome: thrombin generation in healthy individuals

Ann Gils
Modulation of TAFI function through different pathways-implications for the development of TAFI inhibitors

Eirini Nestoridi
Shiga toxin enhances functional tissue factor on human glomerular endothelial cells: implications for the pathophysiology of hemolytic uremic syndrome

Mikhail V Ovanesov
Initiation and propagation of coagulation from tissue factor-bearing cell monolayers to plasma: Initiator cells do not regulate spatial growth rate

Marjolijn van Lier
Adhesive surface determines raft composition in platelets adhered under flow

Best Pictures

WC Aird
Figure 3:"The endothelial color palette."
in Spatial and temporal dynamics of the endothelium

Kashiwagi H, Shiraga M, Kato H, Honda S, Sako M, Kurata Y, Kanakura Y, Tomiyama Y
Figure 4:"Subcellular localization of WAVEs in fully spread platelets."
in Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage

Kumaran V, Benten D, Follenzi A, Joseph B, Sarkar R, Gupta S
Figure 3:"Identification of transplanted cells in tissues."
in Transplantation of endothelial cells corrects the phenotype in hemophilia A mice

Nelson EJR, Li J, Mitchell WB, Chandy M, Srivastava A, Coller BS
Figure 5: "Localization of the b-propeller mutations identified thus far in the aIIbb3 crystal structure."
in Three novel b-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-aIIbb3 from endoplasmic reticulum to Golgi

Nishiyama U, Kuwaki T, Akahori H, Kato T, Ikeda Y, Miyazaki H
Figure 1:"Microscopic images of the thrombus generated in a mesenteric venule."
in Decreased prothrombotic effects of pegylated recombinant human megakaryocyte growth and development factor in thrombocytopenic state in a rat thrombosis model.

Starke R, Harrison P, Mackie I, Wang G, Erusalimsky JD, Gale R, Masse J-M
Figure 5: "Confocal microscopy of CD61 or PrPc in megakaryocytes."
in The expression of prion protein (PrPc) in the megakaryocyte lineage


Ozlem Er

MR Hoppener

Carla Y Vossen

Saskia Schoenmakers

Els Melis

OJT McCarty

E O'Rear

Dr. Dai

Ludovica Piconi

Walter Ageno

A Falco

Best Pictures

Kent Leach

Mieke Dewerchin

Waheed Sangrar

Varsha Kaushal

Harmut Weiler

Aida Inbal



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