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ISTH Guideline on TTP

The ISTH Invites Public Comment on Draft Thrombotic Thrombocytopenic Purpura (TTP) Guidelines

The ISTH welcomes the public to comment on its draft recommendations for the diagnosis and treatment of thrombotic thrombocytopenic purpura (TTP). Clinicians, researchers, allied health professionals, policy makers, industry representatives, patients, caregivers, and other members of the public are welcome to contribute to this process.

The ISTH will only accept responses to its draft recommendations via the online survey below.

The guidelines are based on a systematic review of evidence, followed by structured discussion by a guideline panel comprised of clinical experts, methodologists, and patient representatives. The guideline development process adheres to the recommendations outlined in the Institute of Medicine’s Clinical Practice Guidelines We Can Trust.

Any comments collected during the public comment period will be provided to the guideline panel for review prior to finalizing the guidelines. Comments on content are welcome, however the recommendations – developed using a structured process, formal management of conflict of interest, and anonymous voting by the panel – cannot be altered at this stage. Comments are also considered during multiple steps that follow, including peer review of the guidelines for journal publication, implementation and dissemination efforts following publication, and future revision of the guidelines.

Terms of Use

By downloading and commenting on the draft recommendations, participants agree to adhere to the following terms and conditions of the open comment period:

  • The content of the draft recommendations belongs to and is sole copyright of the International Society on Thrombosis and Haemostasis (ISTH). All rights are reserved by ISTH, and the content may not be in whole or in part reproduced, disseminated, published, distributed, or transferred in any form or by any means, except with the prior written permission of ISTH.
  • Copies of the draft manuscript should not be retained in electronic form, via the Internet, or hardcopy by participants following the submission of their comments.
  • The content available in these recommendations for public comment is in draft form only and is not for use and should not be relied upon in any way in clinical practice or any other medical context. ISTH disclaims all liability resulting from any use of the draft content in these recommendations or the information relied upon therein including, but not limited to, any clinical or medical context. ISTH shall not be liable for any special, consequential, or punitive damages arising from or related to any use or reliance on these recommendations.
  • Participants agree to indemnify, defend, and hold ISTH and its officers, directors, employees, agents, and subcontractors, harmless from all costs, expenses, fees, judgments, and penalties (including any reasonable attorneys’ fees) arising out of any use or reliance upon these draft recommendations.
  • Infringement upon ISTH’s copyright is a violation of US federal law and potentially laws of other countries and subject to criminal and civil penalties. By downloading and commenting on the draft recommendations, participants agree to the exclusive jurisdiction in the state or federal courts located in the United States of America for any dispute arising from these terms of use. In the event of any litigation or arbitration arising out of or relating to these terms of use, the prevailing party shall be entitled to recover its costs and expenses, including reasonable attorneys’ fees.


Public comment is closed. The recommendations are being finalized for publication.

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