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DIC in the ICU
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International prospective registry for the diagnosis and management of disseminated intravascular coagulation in the ICU


Objective:  The primary aim of the Subcommittee on Disseminated Intravascular Coagulation's prospective registry is to assess the current diagnostic and therapeutic approaches for DIC, and in particular for sepsis-associated DIC. Evaluation of the current diagnostic and therapeutic approaches for patients with DIC admitted to ICU and assessment of their effect on prognosis in a large prospective registry will allow to:

  • Assess to what extent the ISTH guidelines are followed in routine clinical practice
  • Formulate new recommendations and guidance on the optimal management of DIC
  • Plan educational initiatives to improve correct knowledge in DIC diagnosis and treatment

In addition, the study will explore the value of clinical and laboratory variables as well as of prognostic scores in the prediction of DIC, 28-day overall mortality, thrombotic; and bleeding complication and, the efficacy and safety of treatments for DIC.

Principal Investigators:  Alessandro Squizzato, MD, PhD (University of Insubria), Marcello Di Nisio, PhD (University G. D'Annunzio)

Registry population: The studied population will consist of patients 18 years or older with diseases potentially associated with DIC.  The clinical visits and monitoring of the patients will follow local routine practices. No specific imaging tests or laboratory evaluations will be required and patients will be evaluated and treated according to local policy. All the involved centers will be asked to update information on included patients at 2, 4, 6, 8, 10 and 28 days after inclusion

Sample size and analysis:  The registry plans to enroll a minimum of 1000 patients in approximately 30 centers. The recruitment phase is estimated to take two years. 

Expected timeline:  Reporting June 2020

Interested participants:  For those interested to participant in this ISTH initiative and working in a ICU with a high volume of patients, contact or

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